Heralding a new paradigm in 3D tumor modeling
Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …
from the traditional two-dimensional culture system to three-dimensional (3D) culture …
Recent advances in microfluidic devices for single-cell cultivation: methods and applications
Single-cell analysis is essential to improve our understanding of cell functionality from
cellular and subcellular aspects for diagnosis and therapy. Single-cell cultivation is one of …
cellular and subcellular aspects for diagnosis and therapy. Single-cell cultivation is one of …
Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis
Tumour microenvironment greatly influences the development and metastasis of cancer
progression. The development of three dimensional (3D) culture models which mimic that …
progression. The development of three dimensional (3D) culture models which mimic that …
Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models
Angiogenesis, the outgrowth of blood vessels, is crucial in development, disease and
regeneration. Studying angiogenesis in vitro remains challenging because the capillary …
regeneration. Studying angiogenesis in vitro remains challenging because the capillary …
Microfluidic tumor–vascular model to study breast cancer cell invasion and intravasation
Cancer is a major leading cause of disease‐related death in the world. The severe impact of
cancer can be attributed to poor understanding of the mechanisms involved in earliest steps …
cancer can be attributed to poor understanding of the mechanisms involved in earliest steps …
Differences in growth properties of endometrial cancer in three dimensional (3D) culture and 2D cell monolayer
Abstract Three-dimensional (3D) in vitro models have an invaluable role in understanding
the behaviour of tumour cells in a well defined microenvironment. This is because some …
the behaviour of tumour cells in a well defined microenvironment. This is because some …
Screening therapeutic EMT blocking agents in a three-dimensional microenvironment
Epithelial–mesenchymal transition (EMT) plays a critical role in the early stages of
dissemination of carcinoma leading to metastatic tumors, which are responsible for over …
dissemination of carcinoma leading to metastatic tumors, which are responsible for over …
The variety of 3D breast cancer models for the study of tumor physiology and drug screening
E Fröhlich - International Journal of Molecular Sciences, 2023 - mdpi.com
Breast cancer is the most common cancer in women and responsible for multiple deaths
worldwide. 3D cancer models enable a better representation of tumor physiology than the …
worldwide. 3D cancer models enable a better representation of tumor physiology than the …
Three-dimensional cultures of mouse mammary epithelial cells
R Mroue, MJ Bissell - Epithelial Cell Culture Protocols: Second Edition, 2013 - Springer
The mammary gland is an ideal “model organism” for studying tissue specificity and gene
expression in mammals: it is one of the few organs that develop after birth and it undergoes …
expression in mammals: it is one of the few organs that develop after birth and it undergoes …
Endothelial induced EMT in breast epithelial cells with stem cell properties
V Sigurdsson, B Hilmarsdottir, H Sigmundsdottir… - PloS one, 2011 - journals.plos.org
Epithelial to mesenchymal transition (EMT) is a critical event in cancer progression and is
closely linked to the breast epithelial cancer stem cell phenotype. Given the close interaction …
closely linked to the breast epithelial cancer stem cell phenotype. Given the close interaction …