Liquid biopsy at the frontier in renal cell carcinoma: recent analysis of techniques and clinical application

M Li, L Li, J Zheng, Z Li, S Li, K Wang, X Chen - Molecular Cancer, 2023 - Springer
Renal cell carcinoma (RCC) is a major pathological type of kidney cancer and is one of the
most common malignancies worldwide. The unremarkable symptoms of early stages …

Risks from deferring treatment for genitourinary cancers: a collaborative review to aid triage and management during the COVID-19 pandemic

CJD Wallis, G Novara, L Marandino, A Bex, AM Kamat… - European urology, 2020 - Elsevier
Context The coronavirus disease 2019 (COVID-19) pandemic is leading to delays in the
treatment of many urologic cancers. Objective To provide a contemporary picture of the risks …

Anti–PD-1 and anti–PD-L1 in head and neck cancer: a network meta-analysis

A Botticelli, A Cirillo, L Strigari, F Valentini… - Frontiers in …, 2021 - frontiersin.org
Objective The monoclonal antibodies anti-programmed death protein-1 (anti–PD-1)
nivolumab and pembrolizumab are the first immune checkpoint inhibitors (ICIs) approved for …

RRM2 regulates sensitivity to sunitinib and PD‐1 blockade in renal cancer by stabilizing ANXA1 and activating the AKT pathway

W Xiong, B Zhang, H Yu, L Zhu, L Yi, X Jin - Advanced science, 2021 - Wiley Online Library
Renal cell carcinoma (RCC) is a malignant tumor of the kidneys. Approximately 70% of RCC
cases are clear cell renal cell carcinoma with von Hippel–Lindau (VHL) gene mutation and …

[HTML][HTML] Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma

C Zhang, L Chen, Y Liu, J Huang, A Liu, Y Xu… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Methyltransferase-like 14 (METTL14) participates in tumorigenesis in several
malignancies, but how METTL14 mediates the metastasis of renal cell carcinoma (RCC) has …

Tyrosine kinase inhibitors and immunotherapy combinations in renal cell carcinoma

E Rassy, R Flippot, L Albiges - Therapeutic advances in …, 2020 - journals.sagepub.com
The treatment landscape of metastatic renal cell carcinoma (mRCC) has been transformed
with the advent of antiangiogenics, notably tyrosine kinase inhibitors (TKIs) targeting …

Renal cell carcinoma therapy: current and new drug candidates

O Pontes, S Oliveira-Pinto, F Baltazar, M Costa - Drug Discovery Today, 2022 - Elsevier
Renal cell carcinoma (RCC) is the most common and lethal tumor of the urological system.
Curative treatment of localized RCC includes nephrectomy, radio-ablation, and active …

A living, interactive systematic review and network meta-analysis of first-line treatment of metastatic renal cell carcinoma

IB Riaz, H He, AJ Ryu, R Siddiqi, SAA Naqvi, Y Yao… - European urology, 2021 - Elsevier
Context Identifying the most effective first-line treatment for metastatic renal cell carcinoma
(mRCC) is challenging as rapidly evolving data quickly outdate the existing body of …

Comparative safety of tyrosine kinase inhibitors in the treatment of metastatic renal cell carcinoma: a systematic review and network meta-analysis

K Krawczyk, K Śladowska, P Holko… - Frontiers in …, 2023 - frontiersin.org
Objective: This study aimed to compare the safety profile of tyrosine kinase inhibitors (TKIs)
approved for use as monotherapy or combination therapy for the first-line treatment of adult …

Epstein–Barr Virus (EBV) Epithelial Associated Malignancies: Exploring Pathologies and Current Treatments

O Shechter, DG Sausen, ES Gallo, H Dahari… - International Journal of …, 2022 - mdpi.com
Epstein–Barr virus (EBV) is one of eight known herpesviruses with the potential to infect
humans. Globally, it is estimated that between 90–95% of the population has been infected …