Immune-escape hepatitis B virus mutations associated with viral reactivation upon immunosuppression

I Lazarevic, A Banko, D Miljanovic, M Cupic - Viruses, 2019 - mdpi.com
Hepatitis B virus (HBV) reactivation occurs as a major complication of immunosuppressive
therapy among persons who have recovered from acute hepatitis and those who have …

Novel biomarkers of hepatitis B virus and their use in chronic hepatitis B patient management

A Vachon, C Osiowy - Viruses, 2021 - mdpi.com
Even though an approved vaccine for hepatitis B virus (HBV) is available and widely used,
over 257 million individuals worldwide are living with chronic hepatitis B (CHB) who require …

Naturally occurring hepatitis B virus mutations leading to endoplasmic reticulum stress and their contribution to the progression of hepatocellular carcinoma

YM Choi, SY Lee, BJ Kim - International Journal of Molecular Sciences, 2019 - mdpi.com
Hepatitis B virus (HBV) infection is a global health problem that causes a wide range of
pathological outcomes, including cirrhosis and hepatocellular carcinoma (HCC) …

Design of aptamer-based sensing platform using gold nanoparticles functionalized reduced graphene oxide for ultrasensitive detection of Hepatitis B virus

DH Mohsin, MS Mashkour, F Fatemi - Chemical Papers, 2021 - Springer
In the present work, electrochemical aptasensor for earlier detection of Hepatitis B virus
infection was developed. First, the surface of a glassy carbon electrode was modified with …

[HTML][HTML] Occult hepatitis B virus infection in hepatic diseases and its significance for the WHO's elimination plan of viral hepatitis

L Bucio-Ortiz, K Enriquez-Navarro… - Pathogens, 2024 - mdpi.com
Liver damage can progress through different stages, resulting in cirrhosis or hepatocellular
carcinoma (HCC), conditions that are often associated with viral infections. Globally, 42 …

The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis

F Kong, H You, D Kong, K Zheng, R Tang - Virology journal, 2019 - Springer
Background The ubiquitin proteasome system (UPS) regulates the expression levels of
cellular proteins by ubiquitination of protein substrates followed by their degradation via the …

Peripheral immune cells exhaustion and functional impairment in patients with chronic hepatitis b

X Jin, Z Yan, L Lu, S Lu, G Zhang, W Lin - Frontiers in Medicine, 2021 - frontiersin.org
After infection of hepatitis B virus (HBV), the virus induces a variety of immune disorders in
the host, leading to immune escape and, finally, the chronicity of the disease. This study …

[HTML][HTML] Hepatitis B Surface Antigen Isoforms: Their Clinical Implications, Utilisation in Diagnosis, Prevention and New Antiviral Strategies

I Lazarevic, A Banko, D Miljanovic, M Cupic - Pathogens, 2024 - mdpi.com
The hepatitis B surface antigen (HBsAg) is a multifunctional glycoprotein composed of large
(LHB), middle (MHB), and small (SHB) subunits. HBsAg isoforms have numerous biological …

Scratching the surface takes a Toll: Immune recognition of viral proteins by surface toll-like receptors

AA Hatton, FE Guerra - Viruses, 2022 - mdpi.com
Early innate viral recognition by the host is critical for the rapid response and subsequent
clearance of an infection. Innate immune cells patrol sites of infection to detect and respond …

CD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants

N Qiu, A Srikanth, M Mulaw, U Tharehalli… - …, 2023 - Taylor & Francis
The expression of viral antigens in chronic hepatitis B virus (HBV) infection drives
continuous liver inflammation, one of the main risk factors to develop liver cancer. HBV …