HIV associated neurocognitive disorders (HAND) are the spectrum of cognitive impairments
present in patients infected with human immunodeficiency virus type 1 (HIV-1). The number …

Background: Mental disorders that are comorbid with chronic infectious diseases may
worsen clinical outcomes and patients' quality of life. We hypothesized that depression …

HIV-1 associated neurocognitive disorder (HAND) is characterized by neuroinflammation
and glial activation that, together with the release of viral proteins, trigger a pathogenic …

Despite effective antiretroviral therapy (ART), HIV-associated neurocognitive disorders
(HAND) are found in nearly one-third of patients. Using a cellular co-culture system …

Human Immunodeficiency virus (HIV) enters the brain soon after seroconversion and
induces chronic neuroinflammation by infecting and activating brain macrophages …

Central nervous system (CNS) complications resulting from HIV infection remain a major
public health problem as individuals live longer due to the success of combined …

The central nervous system (CNS) is a very challenging HIV-1 sanctuary, in which HIV-1
replication is established early on during acute infection and can persist despite potent …

The widespread use of combination antiretroviral therapy (cART) has resulted in significantly
reduced deaths from HIV-1 associated complications and opportunistic infections. However …

Neuroinflammation and synaptodendritic damage represent the pathological hallmarks of
HIV-1 associated cognitive disorders (HAND). The post-synaptic protein neurogranin (Nrgn) …

Studying neurological diseases have long been hampered by the lack of physiologically
relevant models to resemble the complex human brain and the associated pathologies …