Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects

M Stýblo, A Venkatratnam, RC Fry, DJ Thomas - Archives of toxicology, 2021 - Springer
The toxic metalloid inorganic arsenic (iAs) is widely distributed in the environment. Chronic
exposure to iAs from environmental sources has been linked to a variety of human diseases …

[HTML][HTML] Glutathione protects against the meiotic defects of ovine oocytes induced by arsenic exposure via the inhibition of mitochondrial dysfunctions

J Ren, S Li, C Wang, Y Hao, Z Liu, Y Ma, G Liu… - … and Environmental Safety, 2022 - Elsevier
Accumulating evidences revealed the connections between arsenic exposure and
mitochondrial dysfunctions induced reproductive toxicology. Meanwhile, production declines …

Intrauterine arsenic exposure induces glucose metabolism disorders in adult offspring by targeting TET2-mediated DNA hydroxymethylation reprogramming of HNF4α …

X Peng, H Li, D Wang, L Wu, J Hu, F Ye… - Journal of Hazardous …, 2024 - Elsevier
Exposure to arsenic during gestation has lasting health-related effects on the developing
fetus, including an increase in the risk of metabolic disease later in life. Epigenetics is a …

Sex-specific transgenerational effects of preconception exposure to arsenite: metabolic phenotypes of C57BL/6 offspring

B Shang, A Venkatratnam, T Liu, C Douillet, Q Shi… - Archives of …, 2023 - Springer
Chronic exposure to inorganic arsenic (iAs) has been linked to diabetes in both humans and
mice, but the role of iAs exposure prior to conception and its transgenerational effects are …

Heritable dysregulation of DNA methylation may underlie the diabetogenic effects of paternal preconception exposure to inorganic arsenic in C57BL/6J mice

HJ Hartwell, B Shang, C Douillet, AG Bousquet… - Toxicology and Applied …, 2025 - Elsevier
Chronic exposure to inorganic arsenic (iAs) has been linked with the development of
diabetes mellitus (DM). We recently showed that parental exposure to iAs (200 ppb) prior to …

[PDF][PDF] Endocrine Disrupting Chemicals: Threats to Human Health

AC Gore, MA La Merrill, HB Patisaul, RM Sargis - 2024 - endocrine.org
Founded in 1916, the Endocrine Society is the world's oldest, largest, and most active
organization devoted to research on hormones and the clinical practice of endocrinology …

Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells

B Shang, A Venkatratnam, H Hartwell, C Douillet… - Toxicology and applied …, 2022 - Elsevier
We have previously reported that preconception exposure to iAs may contribute to the
development of diabetes in mouse offspring by altering gene expressions in paternal sperm …

Exposure to 3, 3′, 4, 4′, 5-Pentachlorobiphenyl (PCB126) Causes Widespread DNA Hypomethylation in Adult Zebrafish Testis

N Aluru, J Engelhardt - Toxicological Sciences, 2022 - academic.oup.com
Exposure to environmental toxicants during preconception has been shown to affect
offspring health and epigenetic mechanisms such as DNA methylation are hypothesized to …

Health effects of preconception, prenatal, and early-life exposure to inorganic arsenic

AE Enggasser, RC Fry - Handbook of Arsenic Toxicology, 2023 - Elsevier
Exposure to inorganic arsenic that occurs prenatally and/or early in life is associated with
numerous adverse health outcomes. These adverse health outcomes are apparent both …

Arsenic Exposure in C57BL/6 Mice Carrying Human AS3MT Elevates Fasting Glycemia and Impairs Beta Cell Function According to Sex and Developmental Window …

N Singh - 2024 - cdr.lib.unc.edu
Inorganic arsenic (iAs) is a common drinking water contaminant. Chronic exposure to iAs
has been linked to various adverse outcomes, including diabetes, in both epidemiological …