The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Wnt proteins are now recognized as one of the major families of developmentally important
signaling molecules, with mutations in Wnt genes displaying remarkable phenotypes in the …

The mitochondrial unfolded protein response (UPR mt) can be triggered in a cell-non-
autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The …

▪ Abstract Wnt genes encode a large family of secreted, cysteine-rich proteins that play key
roles as intercellular signaling molecules in development. Genetic studies in Drosophila and …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

Wnt genes and components of Wnt signalling pathways have been implicated in a wide
spectrum of important biological phenomena, ranging from early organismal development to …

Wnt pathways are involved in the control of gene expression, cell behavior, cell adhesion,
and cell polarity. In addition, they often operate in combination with other signaling …

Wnts are secreted proteins that are essential for a wide array of developmental and
physiological processes. They signal across the plasma membrane by interacting with …

Wnts compromise a large family of secreted, hydrophobic glycoproteins that control a variety
of developmental and adult processes in all metazoan organisms. Recent advances in the …

In a 4-cell stage C. elegans embryo, signaling by the P 2 blastomere induces anterior–
posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have …