Cyclophosphamide (CP) is used to treat a wide range of neoplastic diseases as well as
some non-malignant ones such as rheumatoid arthritis. It is also used as an …

The evolution of testing strategies and methods for identification of mutagenic agents is
discussed, beginning with the concern over potential health and population effects of …

Blood is the obvious tissue of choice for monitoring DNA damage in the human population,
as it is the most easily obtained tissue. Several genetic endpoints are used to measure …

Somatic mutations can now be quantified in almost any cell type in mice carrying bacterial
genes in a lambda phage shuttle vector. Mutations induced in vivo are detectable ex vivo …

We have determined the mutational spectrum of N-ethyl-N-nitrosourea (ENU) in exon 3 of
the hypoxanthine (guanine) phosphoribosyltransferase gene (Hprt) in splenic T cells …

The development of mouse models with the endogenous hypoxanthineguanine
phosphoribosyl transferase (hprt) gene and lacI transgene as mutational targets provides an …

The role of DNA alkylation at the O 6 position of guanine in the induction of gene mutations
in vivo was studied in the hprt gene of rat T-lymphocytes from spleen exposed in vivo to the …

Experiments were performed to investigate the impact of zidovudine (AZT), lamivudine
(3TC), and abacavir (ABC) on cell survival and mutagenicity in two reporter genes …

We have developed a limiting dilution clonal assay for determining the frequency of 6‐
thioguanine‐resistant (TGr) lymphocytes produced in rats by in vivo exposure to genotoxic …

We have developed an approach for determining mutational spectra in exon 3 of the
hypoxanthineguanine phosphoribosyl transferase (hprt) gene in splenic T-lymphocytes of …