Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis

H Li, XH Yu, X Ou, XP Ouyang, CK Tang - Progress in lipid research, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

[PDF][PDF] HDL biogenesis, remodeling, and catabolism

VI Zannis, P Fotakis, G Koukos, D Kardassis… - Handb Exp …, 2015 - library.oapen.org
In this chapter, we review how HDL is generated, remodeled, and catabolized in plasma. We
describe key features of the proteins that participate in these processes, emphasizing how …

miR-33 links SREBP-2 induction to repression of sterol transporters

TJ Marquart, RM Allen, DS Ory… - Proceedings of the …, 2010 - National Acad Sciences
The sterol regulatory element binding protein 2 (SREBP-2) and the liver X receptor (LXR)
control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and …

Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation

I Gerin, LA Clerbaux, O Haumont, N Lanthier… - Journal of Biological …, 2010 - ASBMB
The regulation of synthesis, degradation, and distribution of lipids is crucial for homeostasis
of organisms and cells. The sterol regulatory element-binding protein (SREBP) transcription …

Regulation of high-density lipoprotein metabolism

KA Rye, PJ Barter - Circulation research, 2014 - Am Heart Assoc
There is compelling evidence from human population studies that plasma levels of high-
density lipoprotein (HDL) cholesterol correlate inversely with cardiovascular risk …

Regulation of ABCA1 functions by signaling pathways

Y Liu, C Tang - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2012 - Elsevier
ATP-binding cassette transporter A1 (ABCA1) is an integral cell membrane protein that
protects cardiovascular disease by at least two mechanisms: by export of excess cholesterol …

Hepatic CTP: phosphocholine cytidylyltransferase-α is a critical predictor of plasma high density lipoprotein and very low density lipoprotein

RL Jacobs, S Lingrell, Y Zhao, GA Francis… - Journal of Biological …, 2008 - ASBMB
CTP: phosphocholine cytidylyltransferase (CT) is the key regulatory enzyme in the CDP-
choline pathway for the biosynthesis of phosphatidylcholine (PC). We previously generated …

The membrane lipid phosphatidylcholine is an unexpected source of triacylglycerol in the liver

JN Van Der Veen, S Lingrell, DE Vance - Journal of Biological Chemistry, 2012 - ASBMB
The increased prevalence of obesity and diabetes in human populations can induce the
deposition of fat (triacylglycerol) in the liver (steatosis). The current view is that most hepatic …

[HTML][HTML] The ABCs of sterol transport

Á Baldán, DD Bojanic, PA Edwards - Journal of lipid research, 2009 - ncbi.nlm.nih.gov
Mammalian cells have developed various responses to minimize accumulation of
unesterified cholesterol, as the latter can result in cell toxicity and death [reviewed in this …

High-density lipoprotein metabolism and function in cardiovascular diseases: what about aging and diet effects?

M Morvaridzadeh, N Zoubdane, J Heshmati, M Alami… - Nutrients, 2024 - mdpi.com
Cardiovascular diseases (CVDs) have become the leading global cause of mortality,
prompting a heightened focus on identifying precise indicators for their assessment and …