Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the
stability and regulation of the endocrine system of the body or its offspring. These …

Preeclampsia (PE) results in placental dysfunction and is one of the primary causes of
maternal and fetal mortality and morbidity. During pregnancy, estrogen is produced primarily …

Estrogen receptor beta (ER-β) regulates diverse physiological functions in the human body.
Current studies are confined to ER-β1, and the functional roles of isoforms 2, 4, and 5 …

The trophoblast, ie the peripheral part of the human conceptus, exerts a crucial role in
implantation and placentation. Both processes properly occur as a consequence of an …

We observed previously that estrogen treatment increased the transcript levels of several
mitochondrial DNA (mtDNA)-encoded genes for mitochondrial respiratory chain (MRC) …

The discovery of the second estrogen receptor (ER) in 1995 surprised many
endocrinologists and resulted in some scepticism regarding its physiological importance …

Estrogens, mainly 17β-estradiol (E2), play a critical role in reproductive organogenesis,
ovulation, and fertility via estrogen receptors. E2 is also a well-known regulator of utero …

During human and nonhuman primate pregnancy, an extensive blood vessel network is
established within the villous placenta to support fetal growth and follicles develop within the …

Aromatase is the enzyme that catalyzes the last step of estrogen biosynthesis. It is
expressed in many tissues such as the gonads, brain and adipose tissue. The regulation of …

Purpose: The aim of this study was to determine the prognostic value of the chemokine
CCL5, considered as a promalignancy factor in breast cancer, in predicting breast cancer …