New data on the pharmacology of tricyclic antidepressants (TCAs), their affinities for human
cloned CNS receptors and their cytochrome P450 enzyme inhibition profiles, allow improved …

The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine,
sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Objective To characterise whether some selective serotonin reuptake inhibitor (SSRI)
antidepressants reduce tamoxifen's effectiveness by inhibiting its bioactivation by …

The selective serotonin reuptake inhibitors (SSRIs) have become the most prescribed
antidepressants in many countries. Although the SSRIs share a common mechanism of …

Objective This review evaluates the in vitro and in vivo evidence for inhibition of cytochrome
P450 enzymes by the newer antidepressants and provides clinical recommendations for …

The cytochromes P450 (CYPs) constitute a superfamily of hemoprotein enzymes that are
responsible for the biotransformation of numerous xenobiotics, including therapeutic agents …

Paroxetine, a selective serotonin reuptake inhibitor, is a potent inhibitor of cytochrome P450
2D6 (CYP2D6) activity, but the mechanism of inhibition is not established. To determine …

Presently in the United States, 21 compounds have been approved by the Food and Drug
Administration as antidepressants. Two additional drugs marketed outside the United States …

Four protease inhibitor antiviral agents (ritonavir, indinavir, nelfinavir, saquinavir) were
evaluated as in vitro inhibitors of the activity of six human cytochromes using an in vitro …