Early life adversity (ELA) is a major risk factor for mental illness, but the neurobiological
mechanisms by which ELA increases the risk for future psychopathology are still poorly …

Stress is recognized as an important issue in basic and clinical neuroscience research,
based upon the founding historical studies by Walter Canon and Hans Selye in the past …

The immediate and long-term effects of exposure to early life stress (ELS) have been
documented in humans and animal models. Even relatively brief periods of stress during the …

Vulnerability to emotional disorders including depression derives from interactions between
genes and environment, especially during sensitive developmental periods. Adverse early …

Stress is an adaptative response aimed at restoring body homeostasis. The classical
neuroendocrine stress response involving the activation of the hypothalamic-pituitary …

There are now robust data supporting the Developmental Origins of Health and Disease
(DOHaD) paradigm. This includes human and animal data focusing on nutrition or …

Major depressive disorder is a common, complex, and potentially life-threatening mental
disorder that imposes a severe social and economic burden worldwide. Over the years …

More than one-third of American adults are obese and statistics are similar worldwide.
Caloric intake and diet composition have large and lasting effects on cognition and emotion …

Environmental challenges are part of daily life for any individual. In fact, stress appears to be
increasingly present in our modern, and demanding, industrialized society. Virtually every …

Over the past decade, advances in both molecular developmental biology and evolutionary
ecology have made possible a new understanding of organisms as dynamic systems …