Toxicomicrobiomics: the human microbiome vs. pharmaceutical, dietary, and environmental xenobiotics

NA Abdelsalam, AT Ramadan, MT ElRakaiby… - Frontiers in …, 2020 - frontiersin.org
The harmful impact of xenobiotics on the environment and human health is being more
widely recognized; yet, inter-and intraindividual genetic variations among humans modulate …

[HTML][HTML] Diversity of vaginal microbiota in sub-Saharan Africa and its effects on HIV transmission and prevention

L Bayigga, DP Kateete, DJ Anderson… - American journal of …, 2019 - Elsevier
The vaginal microbial community (“microbiota”) is a key component of the reproductive
health of women, providing protection against urogenital infections. In sub-Saharan Africa …

Daily vaginal microbiota fluctuations associated with natural hormonal cycle, contraceptives, diet, and exercise

SD Song, KD Acharya, JE Zhu, CM Deveney… - MSphere, 2020 - Am Soc Microbiol
The microorganisms of the vaginal tract are critical for vaginal and reproductive health.
However, the regulation of these microorganisms is not well understood. Therefore, we …

Hormonal contraception alters vaginal microbiota and cytokines in South African adolescents in a randomized trial

C Balle, IN Konstantinus, SZ Jaumdally… - Nature …, 2020 - nature.com
Young women in sub-Saharan Africa are disproportionally affected by HIV infection and
unintended pregnancies. However, hormonal contraceptive (HC) use may influence HIV risk …

Lactobacillus-dominance and rapid stabilization of vaginal microbiota in combined oral contraceptive pill users examined through a longitudinal cohort study with …

S Tuddenham, P Gajer, AE Burke, C Murphy… - …, 2023 - thelancet.com
Background Bacterial vaginosis (BV), a condition in which vaginal Lactobacillus spp. are in
low abundance, is associated with vulvovaginal symptoms, obstetric outcomes and …

Protection and risk: male and female genital microbiota and sexually transmitted infections

S Tuddenham, J Ravel… - The Journal of Infectious …, 2021 - academic.oup.com
Unique compositional and functional features of the cervicovaginal microbiota have been
associated with protection against and risk for sexually transmitted infections (STI). In men …

Copper intrauterine device increases vaginal concentrations of inflammatory anaerobes and depletes lactobacilli compared to hormonal options in a randomized trial

BP Brown, C Feng, RF Tanko, SZ Jaumdally… - Nature …, 2023 - nature.com
Effective contraceptives are a global health imperative for reproductive-aged women.
However, there remains a lack of rigorous data regarding the effects of contraceptive options …

The effect of exogenous sex steroids on the vaginal microbiota: a systematic review

LK Ratten, EL Plummer, CS Bradshaw… - Frontiers in cellular …, 2021 - frontiersin.org
Background Exogenous sex steroids within hormonal contraception and menopausal
hormone therapy (MHT) have been used for family planning and management of …

Connecting the dots: Translating the vaginal microbiome into a drug

LA Lagenaur, A Hemmerling, C Chiu… - The Journal of …, 2021 - academic.oup.com
A Lactobacillus-dominated vaginal microbiota (VMB) has been associated with health and
considered an important host defense mechanism against urogenital infections. Conversely …

The vaginal microbiota, bacterial biofilms and polymeric drug-releasing vaginal rings

L Carson, R Merkatz, E Martinelli, P Boyd, B Variano… - Pharmaceutics, 2021 - mdpi.com
The diversity and dynamics of the microbial species populating the human vagina are
increasingly understood to play a pivotal role in vaginal health. However, our knowledge …