Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

Aims/hypothesis The aim of this study was to use Mendelian randomisation (MR) to identify
the causal risk factors for type 2 diabetes. Methods We first conducted a review of meta …

Circulating proteins are vital in human health and disease and are frequently used as
biomarkers for clinical decision-making or as targets for pharmacological intervention. Here …

Importance Previous in vitro and postmortem research suggests that inflammation may lead
to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range …

PhenoScanner is a curated database of publicly available results from large-scale genetic
association studies. This tool aims to facilitate 'phenome scans', the cross-referencing of …

Mendelian randomization investigations are becoming more powerful and simpler to
perform, due to the increasing size and coverage of genome-wide association studies and …

Plasma levels of the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP)
predict vascular risk with an effect estimate as large as that of total or high-density …

Detailed metabolic profiling in large-scale epidemiologic studies has uncovered novel
biomarkers for cardiometabolic diseases and clarified the molecular associations of …

Circulating cytokines and growth factors are regulators of inflammation and have been
implicated in autoimmune and metabolic diseases. In this genome-wide association study …

While comorbidity between coronary heart disease (CHD) and depression is evident, it is
unclear whether the two diseases have shared underlying mechanisms. We performed a …