Multifunctional Cytochrome c: Learning New Tricks from an Old Dog
Cytochrome c (cyt c) is a small soluble heme protein characterized by a relatively flexible
structure, particularly in the ferric form, such that it is able to sample a broad conformational …
structure, particularly in the ferric form, such that it is able to sample a broad conformational …
Structure and function of heme proteins in non-native states: A mini-review
YW Lin, J Wang - Journal of Inorganic Biochemistry, 2013 - Elsevier
Heme proteins perform various biological functions ranging from electron transfer, oxygen
binding and transport, catalysis, to signaling. Although adopting proper native states is very …
binding and transport, catalysis, to signaling. Although adopting proper native states is very …
Naturally Occurring Disease-Related Mutations in the 40–57 Ω-Loop of Human Cytochrome c Control Triggering of the Alkaline Isomerization
OM Deacon, DA Svistunenko, GR Moore… - Biochemistry, 2018 - ACS Publications
Naturally occurring mutations found in one of the two Ω-loop substructures in human
cytochrome c are associated with low blood platelet count (thrombocytopenia). Both Ω-loops …
cytochrome c are associated with low blood platelet count (thrombocytopenia). Both Ω-loops …
Protein dynamics and function: Making new strides with an old warhorse, the alkaline conformational transition of cytochrome c
MM Cherney, BE Bowler - Coordination Chemistry Reviews, 2011 - Elsevier
Protein dynamics is intimately linked to function. In metalloproteins, dynamics are often
coupled to redox activity, ligand binding and enzyme function. We provide a concise …
coupled to redox activity, ligand binding and enzyme function. We provide a concise …
Adsorbing surface strongly influences the pseudoperoxidase and nitrite reductase activity of electrode-bound yeast cytochrome c. The effect of hydrophobic …
Abstract The Met80Ala and Met80Ala/Tyr67Ala variants of S. cerevisiae iso-1 cytochrome c
(ycc) and their adducts with cardiolipin immobilized onto a gold electrode coated with a …
(ycc) and their adducts with cardiolipin immobilized onto a gold electrode coated with a …
Urea-induced denaturation of immobilized yeast iso-1 cytochrome c: Role of Met80 and Tyr67 in the thermodynamics of unfolding and promotion of pseudoperoxidase …
L Lancellotti, M Borsari, M Bellei, A Bonifacio… - Electrochimica …, 2020 - Elsevier
Abstract The Met80Ala and Met80Ala/Tyr67Ala variants of S. cerevisiae iso-1 cytochrome c
(ycc) immobilized on a decane-1-thiol coated gold electrode subjected to the denaturing …
(ycc) immobilized on a decane-1-thiol coated gold electrode subjected to the denaturing …
[HTML][HTML] An investigation into a cardiolipin acyl chain insertion site in cytochrome c
BS Rajagopal, GG Silkstone, P Nicholls… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Mitochondrial cytochrome c associates with the phosphoplipid cardiolipin (CL) through a
combination of electrostatic and hydrophobic interactions. The latter occurs by insertion into …
combination of electrostatic and hydrophobic interactions. The latter occurs by insertion into …
Immobilized cytochrome c bound to cardiolipin exhibits peculiar oxidation state-dependent axial heme ligation and catalytically reduces dioxygen
Mitochondrial cytochrome c (cytc) plays an important role in programmed cell death upon
binding to cardiolipin (CL), a negatively charged phospholipid of the inner mitochondrial …
binding to cardiolipin (CL), a negatively charged phospholipid of the inner mitochondrial …
Disruption of a hydrogen bond network in human versus spider monkey cytochrome c affects heme crevice stability
ME Goldes, ME Jeakins-Cooley, LJ McClelland… - Journal of inorganic …, 2016 - Elsevier
The hypothesis that the recent rapid evolution of primate cytochromes c, which primarily
involves residues in the least stable Ω-loop (Ω-loop C, residues 40–57), stabilizes the heme …
involves residues in the least stable Ω-loop (Ω-loop C, residues 40–57), stabilizes the heme …
A bis-histidine-ligated unfolded cytochrome c immobilized on anionic SAM shows pseudo-peroxidase activity
Urea-unfolded yeast iso-1-cytochrome c electrostatically adsorbed on a gold electrode
coated with an anionic self-assembled monolayer yields a heme-mediated electrocatalytic …
coated with an anionic self-assembled monolayer yields a heme-mediated electrocatalytic …