Multidrug-resistant (MDR) Gram-negative pathogens remain an unmet public health threat.
In recent times, increased rates of resistance have been reported not only to commonly used …

Essential oils are a complex mixture of aromatic substances whose pharmacological
actions, including antimicrobial, antioxidant, anticancer, and anti-inflammatory activities …

Outer membrane vesicles (OMVs) secreted by Gram-negative bacteria serve as transporters
for the delivery of cargo such as virulence and antibiotic resistance factors. OMVs play a key …

Multidrug-resistant Klebsiella pneumoniae (MDR-Kp) poses a looming health threat to
humans. Clinicians find difficulties in treating MDR-Kp infections in patients with severe …

This untargeted metabolomics study investigated the synergistic antibacterial activity of
polymyxin B and Leu10-teixobactin, a depsipeptide inhibitor of cell wall biosynthesis …

Colistin is a last-line antibiotic which acts by causing membrane permeabilization in Gram-
negative bacteria. However, its clinical value has been limited by its toxicity and the …

Caspofungin is a drug that is used for fungal infections that are difficult to treat, including
invasive aspergillosis and candidemia, as well as other forms of invasive candidiasis. The …

Here, we employed an integrated metabolomics and transcriptomics approach to investigate
the molecular mechanism (s) of action of ceftazidime/avibactam against a pan-drug-resistant …

Nitrofurantoin is a commonly used chemotherapeutic agent in the treatment of
uncomplicated urinary tract infections caused by the problematic multidrug resistant Gram …

Quorum sensing (QS) is considered an appealing target for interference with bacterial
infections. β-Adrenergic blockers are promising anti-QS agents but do not have antibacterial …