Following their discovery over 50 years ago, mesenchymal stromal cells (MSCs) have
become one of the most studied cellular therapeutic products by both academia and industry …

Osteoarthritis (OA) is a common degenerative disease that affects the vast majority of the
elderly and may eventually embark on the road of the total knee arthroplasty (TKA), although …

Background MSCs isolated from bone marrow (BM-MSCs) have well-established
chondrogenic potential, but MSCs derived from the synovial membrane (SM-MSCs) and …

Cell-based therapy for articular hyaline cartilage regeneration predominantly involves the
use of mesenchymal stem cells and chondrocytes. However, the regenerated repair tissue is …

Recently, the research on stemness and multilineage differentiation mechanisms has greatly
increased its value due to the potential therapeutic impact of stem cell-based approaches …

Background Medical interventions for subchondral bone cysts in horses have been
extensively studied. This study investigated the regeneration of articular cartilage and …

Abstract Hypoxia/reoxygenation (H/R) may play an important role via senescence in the
mechanism of osteoarthritis (OA) development. The synovial membrane is highly sensitive to …

Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a
huge burden on the health care system worldwide. Although traditional therapy and targeted …

Temporomandibular disorders are a common cause of chronic pain in the orofacial region
and have a complex and multi-factorial pathophysiology. Mechanical loading or …

Objectives. Osteochondral defects (OCDs) are localized areas of damaged cartilage and
underlying subchondral bone that can produce pain and seriously impair joint function …