Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

Cardiovascular disease (CVD) is the leading cause of death and disability worldwide, and
experiences of psychological trauma have been associated with subsequent CVD onset …

This manuscript reviews recent evidence supporting the utility of telomeres and
mitochondrial DNA copy number (mtDNAcn) in detecting the biological impacts of adverse …

Severe socioeconomic deprivation (SED) and adverse childhood experiences (ACE) are
significantly associated with the development in adulthood of (i) enhanced inflammatory …

Psychosocial stress contributes to placental oxidative stress. Mitochondria are vulnerable to
oxidative stress, which can lead to changes in mitochondrial DNA copy number (mtDNAcn) …

Traumatic stress may chronically affect master homeostatic systems at the crossroads of
peripheral and central susceptibility pathways and lead to the biological embedment of …

Traumatic events during childhood/early adolescence can cause long-lasting physiological
and behavioral changes with increasing risk for psychiatric conditions including psychosis …

Major depressive disorder (MDD) is one of the most prevalent stress-related mental
disorders worldwide. Several biological mechanisms underlying the pathophysiology of …

Childhood maltreatment (CM) is associated with an increased risk for the development of
psychiatric and somatic diseases in later life. Individual risk and resilience factors may …

Early life trauma (ELT) may increase the risk towards bipolar disorder (BD) and major
depression (MDD), disorders associated with activated neuro-oxidative and neuro …