Recurrent urinary tract infection: a mystery in search of better model systems

BO Murray, C Flores, C Williams… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …

Microfluidic tissue engineering and bio‐actuation

M Filippi, T Buchner, O Yasa, S Weirich… - Advanced …, 2022 - Wiley Online Library
Bio‐hybrid technologies aim to replicate the unique capabilities of biological systems that
could surpass advanced artificial technologies. Soft bio‐hybrid robots consist of synthetic …

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

A Marsano, C Conficconi, M Lemme, P Occhetta… - Lab on a Chip, 2016 - pubs.rsc.org
In the past few years, microfluidic-based technology has developed microscale models
recapitulating key physical and biological cues typical of the native myocardium. However …

Naturally engineered maturation of cardiomyocytes

GJ Scuderi, J Butcher - Frontiers in cell and developmental biology, 2017 - frontiersin.org
Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

Heart on a chip: micro-nanofabrication and microfluidics steering the future of cardiac tissue engineering

M Kitsara, D Kontziampasis, O Agbulut… - Microelectronic …, 2019 - Elsevier
The evolution of micro and nanofabrication approaches significantly spurred the
advancements of cardiac tissue engineering over the last decades. Engineering in the micro …

Mimicking human pathophysiology in organ‐on‐chip devices

O Yesil‐Celiktas, S Hassan, AK Miri… - Advanced …, 2018 - Wiley Online Library
Convergence of life sciences, engineering, and basic sciences has opened new horizons for
biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms …

Human induced pluripotent stem-cell-derived cardiomyocytes as models for genetic cardiomyopathies

A Brodehl, H Ebbinghaus, MA Deutsch… - International journal of …, 2019 - mdpi.com
In the last few decades, many pathogenic or likely pathogenic genetic mutations in over
hundred different genes have been described for non-ischemic, genetic cardiomyopathies …

Heart-on-a-chip based on stem cell biology

E Jastrzebska, E Tomecka, I Jesion - Biosensors and Bioelectronics, 2016 - Elsevier
Heart diseases are one of the main causes of death around the world. The great challenge
for scientists is to develop new therapeutic methods for these types of ailments. Stem cells …

Organ-on-a-chip: new platform for biological analysis

F An, Y Qu, X Liu, R Zhong… - AnAlyticAl chemistry …, 2015 - journals.sagepub.com
Direct detection and analysis of biomolecules and cells in physiological microenvironment is
urgently needed for fast evaluation of biology and pharmacy. The past several years have …

[HTML][HTML] A microscale biomimetic platform for generation and electro-mechanical stimulation of 3D cardiac microtissues

R Visone, G Talò, P Occhetta, D Cruz-Moreira… - APL …, 2018 - pubs.aip.org
Organs-on-chip technology has recently emerged as a promising tool to generate advanced
cardiac tissue in vitro models, by recapitulating key physiological cues of the native …