[HTML][HTML] Applications of nanotechnology in drug delivery to the central nervous system

M Saeedi, M Eslamifar, K Khezri, SM Dizaj - Biomedicine & …, 2019 - Elsevier
In recent years, the researchers and drug designers have given growing attention to new
nanotechnology strategies to improve drug delivery to the central nervous system (CNS) …

Biodegradable polymer nanogels for drug/nucleic acid delivery

Y Li, D Maciel, J Rodrigues, X Shi, H Tomás - Chemical reviews, 2015 - ACS Publications
Despite the extensive research on therapeutic delivery, many problems still exist on how to
develop a proper platform (a carrier) that can deliver drugs/nucleic acids to specific sites of …

Nanogels as novel drug nanocarriers for CNS drug delivery

V Manimaran, RP Nivetha, T Tamilanban… - Frontiers in Molecular …, 2023 - frontiersin.org
Nanogels are highly recognized as adaptable drug delivery systems that significantly
contribute to improving various therapies and diagnostic examinations for different human …

Nano carriers for drug transport across the blood–brain barrier

X Li, J Tsibouklis, T Weng, B Zhang, G Yin… - Journal of drug …, 2017 - Taylor & Francis
Effective therapy lies in achieving a therapeutic amount of drug to the proper site in the body
and then maintaining the desired drug concentration for a sufficient time interval to be …

Recent expansions of novel strategies towards the drug targeting into the brain

A Alexander, M Agrawal, A Uddin… - International journal …, 2019 - Taylor & Francis
The treatment of central nervous system (CNS) disorders always remains a challenge for the
researchers. The presence of various physiological barriers, primarily the blood–brain …

Brain delivery of curcumin using solid lipid nanoparticles and nanostructured lipid carriers: Preparation, optimization, and pharmacokinetic evaluation

S Sadegh Malvajerd, A Azadi, Z Izadi… - ACS chemical …, 2018 - ACS Publications
Curcumin is a multitherapeutic agent with great therapeutic potential in central nervous
system (CNS) diseases. In the current study, curcumin was encapsulated in solid lipid …

A review of therapeutic challenges and achievements of methotrexate delivery systems for treatment of cancer and rheumatoid arthritis

SS Abolmaali, AM Tamaddon, R Dinarvand - Cancer chemotherapy and …, 2013 - Springer
Purpose Methotrexate (MTX) is one of the most widely studied and effective therapeutics
agents available to treat many solid tumors, hematologic malignancies, and autoimmune …

Nanogels as drug carriers–Introduction, chemical aspects, release mechanisms and potential applications

S Shah, N Rangaraj, K Laxmikeshav… - International Journal of …, 2020 - Elsevier
Nanogels, also known as next generation drug delivery systems are in the limelight of the
research owing to their advantages like high loading, tunability of size, stimuli …

Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders

C Vissers, G Ming, H Song - Advanced drug delivery reviews, 2019 - Elsevier
The convergence of nanoparticles and stem cell therapy holds great promise for the study,
diagnosis, and treatment of neurodegenerative disorders. Researchers aim to harness the …

Nanogels as potential drug nanocarriers for CNS drug delivery

A Vashist, A Kaushik, A Vashist, J Bala… - Drug discovery today, 2018 - Elsevier
Highlights•Nanogels are the nano-sized hydrogel particles exhibiting superior properties
than the conventional bulk hydrogels.•Nanogels are among exciting innovations in …