Phenotypically identical cells can dramatically vary with respect to behavior during their
lifespan and this variation is reflected in their molecular composition such as the …

With the completion of the human genome sequence, attention turned to identifying and
annotating its functional DNA elements. As a complement to genetic and comparative …

Histone modifications and chromatin-associated protein complexes are crucially involved in
the control of gene expression, supervising cell fate decisions and differentiation. Many …

In the last decades, transcriptome profiling has been one of the most utilized approaches to
investigate human diseases at the molecular level. Through expression studies, many …

The human mitochondrial genome comprises a distinct genetic system transcribed as
precursor polycistronic transcripts that are subsequently cleaved to generate individual …

Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …

Cells release RNA-carrying vesicles and membrane-free RNA/protein complexes into the
extracellular milieu. Horizontal vesicle-mediated transfer of such shuttle RNA between cells …

The laboratory mouse shares the majority of its protein-coding genes with humans, making it
the premier model organism in biomedical research, yet the two mammals differ in …

Over the past decade there has been a greater understanding of genomic complexity in
eukaryotes ushered in by the immense technological advances in high-throughput …

Promoters are crucial for gene regulation. They vary greatly in terms of associated regulatory
elements, sequence motifs, the choice of transcription start sites and other features. Several …