[HTML][HTML] The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction
V Kalienkova, VC Mosina, C Paulino - Journal of Molecular Biology, 2021 - Elsevier
The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …
while some family members function as Ca 2+-activated anion channels, the majority of …
[HTML][HTML] The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?
Y Liu, Z Liu, KW Wang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Abstract Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca 2+ activated Cl–
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …
The ion channel function of polycystin‐1 in the polycystin‐1/polycystin‐2 complex
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD 1 or
PKD 2 gene, encoding the polycystic kidney disease protein polycystin‐1 and the transient …
PKD 2 gene, encoding the polycystic kidney disease protein polycystin‐1 and the transient …
Differential phosphorylation of Ca2+-permeable channel CYCLIC NUCLEOTIDE–GATED CHANNEL20 modulates calcium-mediated freezing tolerance in …
Y Peng, Y Ming, B Jiang, X Zhang, D Fu, Q Lin… - The Plant …, 2024 - academic.oup.com
Plants respond to cold stress at multiple levels, including increasing cytosolic calcium
(Ca2+) influx and triggering the expression of cold-responsive genes. In this study, we show …
(Ca2+) influx and triggering the expression of cold-responsive genes. In this study, we show …
A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl− channel ANO1 (TMEM16A)
ANO1 (TMEM16A) is a Ca2+-activated Cl− channel that regulates diverse cellular functions
including fluid secretion, neuronal excitability, and smooth muscle contraction. ANO1 is …
including fluid secretion, neuronal excitability, and smooth muscle contraction. ANO1 is …
Knockin'on egg's door: Maternal control of egg activation that influences cortical granule exocytosis in animal species
J Rojas, F Hinostroza, S Vergara… - Frontiers in Cell and …, 2021 - frontiersin.org
Fertilization by multiple sperm leads to lethal chromosomal number abnormalities, failed
embryo development, and miscarriage. In some vertebrate and invertebrate eggs, the so …
embryo development, and miscarriage. In some vertebrate and invertebrate eggs, the so …
Phosphatidylinositol 4, 5-bisphosphate (PIP2) and Ca2+ are both required to open the Cl− channel TMEM16A
M Tembo, KL Wozniak, RE Bainbridge… - Journal of Biological …, 2019 - ASBMB
Transmembrane member 16A (TMEM16A) is a widely expressed Ca 2+-activated Cl−
channel with various physiological functions ranging from mucosal secretion to regulating …
channel with various physiological functions ranging from mucosal secretion to regulating …
Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels
ABSTRACT Ca2+-activated Cl− channels (CaCCs) perform a multitude of functions
including the control of cell excitability, regulation of cell volume and ionic homeostasis …
including the control of cell excitability, regulation of cell volume and ionic homeostasis …
KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies
PÁ Prado, S Häfner, Y Comoglio, B Wdziekonski… - Cell, 2021 - cell.com
Determination of what is the specificity of subunits composing a protein complex is essential
when studying gene variants on human pathophysiology. The pore-forming α-subunit …
when studying gene variants on human pathophysiology. The pore-forming α-subunit …
Ca2+ signaling and homeostasis in mammalian oocytes and eggs
T Wakai, A Mehregan… - Cold Spring Harbor …, 2019 - cshperspectives.cshlp.org
Changes in the intracellular concentration of calcium ([Ca2+] i) represent a vital signaling
mechanism enabling communication between and among cells as well as with the …
mechanism enabling communication between and among cells as well as with the …