Myeloid-derived suppressor cells (MDSC) have frequently been observed in patients with
cancer. This heterogeneous population of myeloid cells can exert potent suppression of …

In the late 1970s, several findings suggested that accessory cells distinct from lymphocytes
might suppress immune reactivity in tumor-bearing hosts. Studies in animal models and …

Abstract CD11b+ Gr-1+ myeloid suppressor cells (MSC) accumulate in lymphoid organs
under conditions of intense immune stress where they inhibit T and B cell function. We …

Our previous work demonstrated that cytotoxic T lymphocyte (CTL)-mediated tumor
immunosurveillance of the 15-12RM tumor could be suppressed by a CD1d-restricted …

Following an infection or immunization, a primary CD8+ T cell response generally rises then
falls rapidly before giving rise to a “memory” response. When we immunized mice with …

Tumor cells and microorganisms manipulate the immune system to minimize any counter
response in order to survive. Myeloid-derived suppressor cells (MDSC) in the mouse …

Granulocyte-macrophage colony-stimulating factor (GM-CSF) controls proliferation and
survival of myeloid cells including monocytes. Here, we describe a time-dependent licensing …

To find out whether polymorphonuclear neutrophils (PMN), abundantly recruited in
disseminated Candida albicans infection, could directly affect the activation of Th cells we …

We described a generalized suppression of CTL anamnestic responses that occurred in
mice bearing large tumor nodules or immunized with powerful recombinant viral …

The reduced efficiency of the mammalian immune system with aging increases host
susceptibility to infectious and autoimmune diseases. However, the mechanisms …