A survey of deep learning for alzheimer's disease
Alzheimer's and related diseases are significant health issues of this era. The
interdisciplinary use of deep learning in this field has shown great promise and gathered …
interdisciplinary use of deep learning in this field has shown great promise and gathered …
Astrocyte strategies in the energy-efficient brain
I Fernández-González, E Galea - Essays in Biochemistry, 2023 - portlandpress.com
Astrocytes generate ATP through glycolysis and mitochondrion respiration, using glucose,
lactate, fatty acids, amino acids, and ketone bodies as metabolic fuels. Astrocytic …
lactate, fatty acids, amino acids, and ketone bodies as metabolic fuels. Astrocytic …
Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum
Purpose Glial activation is one of the earliest mechanisms to be altered in Alzheimer's
disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be …
disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be …
Emerging role of miR-21-5p in neuron–glia dysregulation and exosome transfer using multiple models of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder associated with neuron–glia
dysfunction and dysregulated miRNAs. We previously reported upregulated miR-124/miR …
dysfunction and dysregulated miRNAs. We previously reported upregulated miR-124/miR …
Neuroinflammation Biomarkers in the AT (N) Framework Across the Alzheimer's Disease Continuum
In the past years, neuroinflammation has been widely investigated in Alzheimer's disease
(AD). Evidence from animal, in vivo and post-mortem studies has shown that inflammatory …
(AD). Evidence from animal, in vivo and post-mortem studies has shown that inflammatory …
16p11. 2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice
A Beland-Millar, A Kirby, Y Truong, J Ouellette… - Cell reports, 2023 - cell.com
Neurovascular abnormalities in mouse models of 16p11. 2 deletion autism syndrome are
reminiscent of alterations reported in murine models of glucose transporter deficiency …
reminiscent of alterations reported in murine models of glucose transporter deficiency …
Altered patterns of brain glucose metabolism involve more extensive and discrete cortical areas in treatment-resistant schizophrenia patients compared to responder …
F Iasevoli, L D'Ambrosio, M Ciccarelli… - Schizophrenia …, 2023 - academic.oup.com
Abstract Background and Hypothesis Treatment resistant schizophrenia (TRS) affects almost
30% of patients with schizophrenia and has been considered a different phenotype of the …
30% of patients with schizophrenia and has been considered a different phenotype of the …
[HTML][HTML] Short-term consumption of highly processed diets varying in macronutrient content impair the sense of smell and brain metabolism in mice
Objective Food processing greatly contributed to increased food safety, diversity, and
accessibility. However, the prevalence of highly palatable and highly processed food in our …
accessibility. However, the prevalence of highly palatable and highly processed food in our …
Astrocyte signature in Alzheimer's disease continuum through a multi-PET tracer imaging perspective
IC Fontana, M Scarpa, ML Malarte, FM Rocha… - Cells, 2023 - mdpi.com
Reactive astrogliosis is an early event in the continuum of Alzheimer's disease (AD). Current
advances in positron emission tomography (PET) imaging provide ways of assessing …
advances in positron emission tomography (PET) imaging provide ways of assessing …
[HTML][HTML] Brain fog in long COVID: A glutamatergic hypothesis with astrocyte dysfunction accounting for brain PET glucose hypometabolism
Abstract Brain [18 F] FDG-PET scans have revealed a glucose hypometabolic pattern in
patients with long COVID. This hypometabolism might reflect primary astrocyte dysfunction …
patients with long COVID. This hypometabolism might reflect primary astrocyte dysfunction …