Role of oxidative stress in depression

S Bhatt, AN Nagappa, CR Patil - Drug discovery today, 2020 - Elsevier
Highlights•The Reactive Oxygen Species have an utmost importance in progression of
Depression.•Depression is associated with lowered concentration of anti-oxidants in …

Prospective biomarkers of major depressive disorder: a systematic review and meta-analysis

M Kennis, L Gerritsen, M van Dalen, A Williams… - Molecular …, 2020 - nature.com
Leading biological hypotheses propose that biological changes may underlie major
depressive disorder onset and relapse/recurrence. Here, we investigate if there is …

Polyunsaturated fatty acids and their metabolites in brain function and disease

RP Bazinet, S Layé - Nature reviews neuroscience, 2014 - nature.com
The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids
(PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the …

The microbiome: stress, health and disease

RD Moloney, L Desbonnet, G Clarke, TG Dinan… - Mammalian …, 2014 - Springer
Bacterial colonisation of the gut plays a major role in postnatal development and maturation
of key systems that have the capacity to influence central nervous system (CNS) …

The impact of microbiota on brain and behavior: mechanisms & therapeutic potential

YE Borre, RD Moloney, G Clarke, TG Dinan… - … : The microbiota-gut …, 2014 - Springer
There is increasing evidence that host-microbe interactions play a key role in maintaining
homeostasis. Alterations in gut microbial composition is associated with marked changes in …

Food for mood: relevance of nutritional omega-3 fatty acids for depression and anxiety

T Larrieu, S Layé - Frontiers in physiology, 2018 - frontiersin.org
The central nervous system (CNS) has the highest concentration of lipids in the organism
after adipose tissue. Among these lipids, the brain is particularly enriched with …

Possible antidepressant mechanisms of omega-3 polyunsaturated fatty acids acting on the central nervous system

L Zhou, JY Xiong, YQ Chai, L Huang, ZY Tang… - Frontiers in …, 2022 - frontiersin.org
Omega-3 polyunsaturated fatty acids (PUFAs) can play important roles in maintaining
mental health and resistance to stress, and omega-3 PUFAs supplementation can display …

The role of omega-3 polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids in the treatment of major depression and Alzheimer's disease: Acting …

C Song, CH Shieh, YS Wu, A Kalueff, S Gaikwad… - Progress in lipid …, 2016 - Elsevier
Omega-3 polyunsaturated fatty acids (n‐3-PUFAs), mainly eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA), may improve or prevent some psychiatric and …

[HTML][HTML] Omega-3 polyunsaturated fatty acids in depression

A Serefko, ME Jach, M Pietraszuk, M Świąder… - International Journal of …, 2024 - mdpi.com
Omega-3 polyunsaturated fatty acids have received considerable attention in the field of
mental health, in particular regarding the treatment of depression. This review presents an …

Effects of oxidative stress on fatty acid‐and one‐carbon‐metabolism in psychiatric and cardiovascular disease comorbidity

J Assies, RJT Mocking, A Lok, HG Ruhé… - Acta Psychiatrica …, 2014 - Wiley Online Library
Objective Cardiovascular disease (CVD) is the leading cause of death in severe psychiatric
disorders (depression, schizophrenia). Here, we provide evidence of how the effects of …