Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility
Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
inaccessible human cell types, yielding new insights into disease mechanisms especially for …
Pluripotent stem cells in disease modelling and drug discovery
Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …
molecular mechanisms underlying diseases and the development of therapies for treating …
The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …
Modeling gene× environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to
which genetic and environmental risk factors contribute to individual clinical outcomes is …
which genetic and environmental risk factors contribute to individual clinical outcomes is …
Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors
We have generated a controlled and manipulable resource that captures genetic risk for
Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic …
Alzheimer's disease: iPSC lines from 53 individuals coupled with RNA and proteomic …
A viral strategy for targeting and manipulating interneurons across vertebrate species
A fundamental impediment to understanding the brain is the availability of inexpensive and
robust methods for targeting and manipulating specific neuronal populations. The need to …
robust methods for targeting and manipulating specific neuronal populations. The need to …
[HTML][HTML] Directed differentiation of human pluripotent stem cells to microglia
P Douvaras, B Sun, M Wang, I Kruglikov, G Lallos… - Stem cell reports, 2017 - cell.com
Microglia, the immune cells of the brain, are crucial to proper development and maintenance
of the CNS, and their involvement in numerous neurological disorders is increasingly being …
of the CNS, and their involvement in numerous neurological disorders is increasingly being …
[HTML][HTML] Stem cell therapy for Alzheimer's disease
XY Liu, LP Yang, L Zhao - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and cognitive impairment. It is caused by synaptic failure and excessive …
memory loss and cognitive impairment. It is caused by synaptic failure and excessive …
Quality control guidelines for clinical-grade human induced pluripotent stem cell lines
S Sullivan, GN Stacey, C Akazawa… - Regenerative …, 2018 - Taylor & Francis
Use of clinical-grade human induced pluripotent stem cell (iPSC) lines as a starting material
for the generation of cellular therapeutics requires demonstration of comparability of lines …
for the generation of cellular therapeutics requires demonstration of comparability of lines …
[HTML][HTML] Cardiomyocytes from human pluripotent stem cells: from laboratory curiosity to industrial biomedical platform
C Denning, V Borgdorff, J Crutchley, KSA Firth… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Cardiomyocytes from human pluripotent stem cells (hPSCs-CMs) could revolutionise
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …
biomedicine. Global burden of heart failure will soon reach USD $90 bn, while unexpected …