Chimeric antigen receptor (CAR) T cells have emerged as a promising class of therapeutic
agents, generating remarkable responses in the clinic for a subset of human cancers. One …

The closely related inhibitory killer-cell immunoglobulin-like receptors (KIR), KIR2DL2 and
KIR2DL3, regulate the activation of natural killer cells (NK) by interacting with the human …

Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …

The KIR (killer-cell immunoglobulin-like receptor) region is characterized by structural
variation and high sequence similarity among genes, imposing technical difficulties for …

The clinical success of immune checkpoint inhibitors has underscored the key role of the
immune system in controlling cancer. Current FDA-approved immune checkpoint inhibitors …

Atopic dermatitis (AD) is a chronic illness that is associated with immune dysregulation. NK
cell function has previously been associated with AD. NK cells directly interact with …

Dimorphic amino acids at positions 77 and 80 delineate HLA-C allotypes into two groups,
C1 and C2, which associate with disease through interactions with C1 and C2-specific …

HLA class I molecules that represent ligands for the inhibitory killer cell Ig-like receptor (KIR)
3DL1 found on NK cells are categorically defined as those HLA-A and HLA-B allotypes …

Immune dysfunction plays a role in the development of Parkinson disease (PD). NK cells
regulate immune functions and are modulated by killer cell immunoglobulin-like receptors …

Delayed drug hypersensitivities are CD8+ T cell–mediated reactions associated with up to
50% mortality. Human leukocyte antigen (HLA) alleles are known to predispose disease and …