Annexins bridging the gap: novel roles in membrane contact site formation

C Enrich, A Lu, F Tebar, C Rentero… - Frontiers in Cell and …, 2022 - frontiersin.org
Membrane contact sites (MCS) are specialized small areas of close apposition between two
different organelles that have led researchers to reconsider the dogma of intercellular …

Repurposing phenothiazines for cancer therapy: compromising membrane integrity in cancer cells

SF Mehrabi, S Elmi, J Nylandsted - Frontiers in Oncology, 2023 - frontiersin.org
The limitations of current cancer therapies, including the increasing prevalence of multidrug
resistance, underscore the urgency for more effective treatments. One promising avenue lies …

ANNEXIN A1: roles in placenta, cell survival, and nucleus

SO Sousa, MR Santos, SC Teixeira, EAV Ferro… - Cells, 2022 - mdpi.com
The unbiased approaches of the last decade have enabled the collection of new data on the
biology of annexin A1 (ANXA1) in a variety of scientific aspects, creating opportunities for …

Annexin A2 plays a key role in protecting against cisplatin-induced AKI through β-catenin/TFEB pathway

K Shen, J Miao, Q Gao, X Ling, Y Liang, Q Zhou… - Cell Death …, 2022 - nature.com
Acute kidney injury (AKI) is in high prevalence in the world. However, the therapeutic
strategies for AKI are still in mystery. Studies have shown to improve autophagy and …

Human myelin protein P2: from crystallography to time‐lapse membrane imaging and neuropathy‐associated variants

M Uusitalo, MB Klenow, S Laulumaa… - The FEBS …, 2021 - Wiley Online Library
Peripheral myelin protein 2 (P2) is a fatty acid‐binding protein expressed in vertebrate
peripheral nervous system myelin, as well as in human astrocytes. Suggested functions of …

Ca2+ and Annexins – Emerging Players for Sensing and Transferring Cholesterol and Phosphoinositides via Membrane Contact Sites

C Enrich, A Lu, F Tebar, C Rentero… - Cholesterol and PI (4, 5) P2 …, 2023 - Springer
Maintaining lipid composition diversity in membranes from different organelles is critical for
numerous cellular processes. However, many lipids are synthesized in the endoplasmic …

Engineering a membrane-binding protein to trimerize and induce high membrane curvature

AAH Zanjani, A Mularski, ASB Heitmann, C Dias… - Biophysical …, 2023 - cell.com
The annexins are a family of C a 2+-dependent peripheral membrane proteins. Several
annexins are implicated in plasma membrane repair and are overexpressed in cancer cells …

Neuroprotective effects of annexin A1 tripeptide in rats with sepsis‐associated encephalopathy

Q Cui, N Qin, Y Zhang, Y Miao, L Xie… - Biotechnology and …, 2024 - Wiley Online Library
Sepsis‐associated encephalopathy (SAE) is characterized by high incidence and mortality
rates, with limited treatment options available. The underlying mechanisms and …

Annexin A1 may contribute to the morphological changes in podocytes by mediating endocytic vesicle fusion and transport via promotion of SNARE assembly in …

L Song, W Shen, L Wang, J Song, W Tu, B Ke… - …, 2024 - Wiley Online Library
Background Annexin A1 is a membrane‐associated calcium‐binding protein that
participates in the progression of many diseases by facilitating vesicle aggregation. It has …

Genetic Characterization of the Cell Types of in Developing Feathers, and the Evolution of Feather Complexity

C Limber, G Wagner, RO Prum - bioRxiv, 2024 - biorxiv.org
Feathers are the most complex and diverse epidermal appendages found in vertebrates.
Their unique hierarchical organization and development is based on a diversity of cell types …