Recent advances in the synthesis of biologically active spirooxindoles

MMM Santos - Tetrahedron, 2014 - Elsevier
The spirooxindole system is the core structure of a variety of medicinal agents and natural
products. 1, 2 In fact, spirooxindole derivatives have been described with different biological …

Recent advances in organocatalytic cascade reactions toward the formation of quaternary stereocenters

F Vetica, RM de Figueiredo, M Orsini, D Tofani… - …, 2015 - thieme-connect.com
This review provides the authors' selection of recent publications that highlight the
increasing efforts to develop valuable organocatalytic domino/tandem/cascade reactions as …

Asymmetric Michael/cyclization cascade reaction of 3-isothiocyanato oxindoles and 3-nitroindoles with amino-thiocarbamate catalysts: enantioselective synthesis of …

JQ Zhao, MQ Zhou, ZJ Wu, ZH Wang, DF Yue… - Organic …, 2015 - ACS Publications
An unprecedented organocatalytic asymmetric Michael/cyclization cascade reaction of 3-
isothiocyanato oxindoles and 3-nitroindoles has been disclosed. A wide range of …

Recent Advances of α‐Isothiocyanato Compounds in the Catalytic Asymmetric Reaction

WY Han, JQ Zhao, J Zuo, XY Xu… - Advanced Synthesis …, 2015 - Wiley Online Library
Abstract α‐Isothiocyanato amides, esters and phosphonates have emerged as new types of
versatile reagents for various organo‐and metal‐catalyzed asymmetric cascade reactions …

Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three …

BD Cui, SW Li, J Zuo, ZJ Wu, XM Zhang, WC Yuan - Tetrahedron, 2014 - Elsevier
An efficient organocatalytic diastereo-and enantioselective method for the construction of
spirocyclic oxindole derivatives bearing two spiro quaternary centers and three consecutive …

A Mannich/cyclization cascade process for the asymmetric synthesis of spirocyclic thioimidazolidineoxindoles

H Cai, Y Zhou, D Zhang, J Xu, H Liu - Chemical Communications, 2014 - pubs.rsc.org
An asymmetric cascade Mannich/cyclization reaction between 3-isothiocyanato oxindoles
and sulfimides using a commercially available organocatalyst has been developed. A wide …

Synthesis of novel spirooxindoles in water by using MnFe2O4 nanoparticles as an efficient magnetically recoverable and reusable catalyst

R Ghahremanzadeh, Z Rashid, AH Zarnani… - Applied Catalysis A …, 2013 - Elsevier
An efficient, clean, atom-economical and simple method for the one-pot synthesis of novel
spirooxindole derivatives via a three-component reaction of isatins, dimedone and …

Tandem Michael addition–ring transformation reactions of 3-hydroxyoxindoles/3-aminooxindoles with olefinic azlactones: direct access to structurally diverse …

BD Cui, J Zuo, JQ Zhao, MQ Zhou, ZJ Wu… - The Journal of …, 2014 - ACS Publications
An efficient method for the direct construction of two classes of spirocyclic oxindoles by the
reactions of 3-hydroxyoxindoles/3-aminooxindoles and (Z)-olefinic azlactones through a …

Organocatalytic asymmetric [3+ 2]-cycloaddition of 3-isothiocyanato oxindoles with 1, 3, 5-trisubstituted-hexahydro-1, 3, 5-triazines to access spiro-imidazolidinethione …

CB Zhang, PH Dou, Y You, ZH Wang, MQ Zhou, XY Xu… - Tetrahedron, 2019 - Elsevier
Abstract An efficient asymmetric [3+ 2]-cycloaddition reaction of 3-isothiocyanato oxindoles
and formaldimines in-situ generated from 1, 3, 5-trisubstituted-hexahydro-1, 3, 5-triazines …

Recent developments on the synthesis and applications of natural products-inspired spirooxindole frameworks

SA Babu, R Padmavathi, NA Aslam… - Studies in Natural …, 2015 - Elsevier
Spirooxindole moiety is an important heterocyclic framework that is present as the core
structural unit in several biologically active synthetic and naturally occurring molecules. The …