Molecular genetics and emerging therapies for retinitis pigmentosa: Basic research and clinical perspectives

MF Dias, K Joo, JA Kemp, SL Fialho… - Progress in retinal and …, 2018 - Elsevier
Retinitis Pigmentosa (RP) is a hereditary retinopathy that affects about 2.5 million people
worldwide. It is characterized with progressive loss of rods and cones and causes severe …

Clinical perspective: treating RPE65-associated retinal dystrophy

AM Maguire, J Bennett, EM Aleman, BP Leroy… - Molecular Therapy, 2021 - cell.com
Until recently, there was no approved treatment for a retinal degenerative disease.
Subretinal injection of a recombinant adeno-associated virus (AAV) delivering the normal …

The Argus® II retinal prosthesis system

YHL Luo, L Da Cruz - Progress in retinal and eye research, 2016 - Elsevier
Abstract The Argus® II Retinal Prosthesis System (Second Sight Medical Products) is the
first prosthetic vision device to obtain regulatory approval in both Europe and the USA. As …

Inherited retinal degenerations: current landscape and knowledge gaps

JL Duncan, EA Pierce, AM Laster… - … vision science & …, 2018 - tvst.arvojournals.org
Inherited retinal degenerations (IRDs) represent a diverse group of progressive, visually
debilitating diseases that can lead to blindness in which mutations in genes that are critical …

Advances in retinal prosthesis systems

E Bloch, Y Luo, L da Cruz - Therapeutic advances in …, 2019 - journals.sagepub.com
Retinal prosthesis systems have undergone significant advances in the past quarter century,
resulting in the development of several different novel surgical and engineering approaches …

Retinal stimulation strategies to restore vision: Fundamentals and systems

L Yue, JD Weiland, B Roska, MS Humayun - Progress in retinal and eye …, 2016 - Elsevier
Retinal degeneration, a leading cause of blindness worldwide, is primarily characterized by
the dysfunctional/degenerated photoreceptors that impair the ability of the retina to detect …

Interim results of a multicenter trial with the new electronic subretinal implant alpha AMS in 15 patients blind from inherited retinal degenerations

K Stingl, R Schippert, KU Bartz-Schmidt… - Frontiers in …, 2017 - frontiersin.org
Purpose: We assessed the safety and efficacy of a technically advanced subretinal
electronic implant, RETINA IMPLANT Alpha AMS, in end stage retinal degeneration in an …

[HTML][HTML] Five-year safety and performance results from the Argus II retinal prosthesis system clinical trial

L da Cruz, JD Dorn, MS Humayun, G Dagnelie… - Ophthalmology, 2016 - Elsevier
Purpose The Argus II Retinal Prosthesis System (Second Sight Medical Products, Inc,
Sylmar, CA) was developed to restore some vision to patients blind as a result of retinitis …

Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas

NAL Chenais, MJI Airaghi Leccardi… - Communications …, 2021 - nature.com
Retinal prostheses hold the promise of restoring vision in totally blind people. However, a
decade of clinical trials highlighted quantitative limitations hampering the possibility of …

Bioengineering strategies for restoring vision

J Cehajic-Kapetanovic, MS Singh, E Zrenner… - Nature biomedical …, 2023 - nature.com
Late-stage retinal degenerative disease involving photoreceptor loss can be treated by
optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to …