Abstract p53, encoded by the tumor suppressor gene TP53, is one of the most important
tumor suppressor factors in vivo and can be negatively regulated by MDM2 through p53 …

Inactivation of the transcription factor p53, through either direct mutation or aberrations in
one of its many regulatory pathways, is a hallmark of virtually every tumor. In recent years …

Stereoconvergent catalysis is an important subset of asymmetric synthesis that
encompasses stereoablative transformations, dynamic kinetic resolutions, and dynamic …

A palladium-catalyzed enantioselective α-allylation of deconjugated butenolides with aza-π-
allylpalladium 1, 4-diploes, in situ generated from palladium-mediated decarboxylation of …

There are current attempts to find a safe substitute or adjuvant for Sorafenib (Sorf), the
standard treatment for advanced hepatocellular carcinoma (HCC), as it triggers very harsh …

MDM2 and MDM4 are key negative regulators of p53, an important protein involved in
several cell processes (eg cell cycle and apoptosis). Not surprisingly, the p53 tumor …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
56417710&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

US10772962B2 - Compounds and methods for the targeted degradation of bromodomain-containing
proteins - Google Patents US10772962B2 - Compounds and methods for the targeted …

Background: Antibiotic resistance is one of the biggest threats to global health today, leading
to higher medical costs and increased mortality. Because of the emergence and rapid …

The tumor suppressor p53 is one of the most important proteins for protection of genomic
stability and cancer prevention. Cancers often inactivate it by either mutating its gene or …