Fibroblast growth factor signalling in the diseased nervous system

L Klimaschewski, P Claus - Molecular Neurobiology, 2021 - Springer
Fibroblast growth factors (FGFs) act as key signalling molecules in brain development,
maintenance, and repair. They influence the intricate relationship between myelinating cells …

Neurotrophins and other growth factors in the pathogenesis of Alzheimer's disease

T Numakawa, R Kajihara - Life, 2023 - mdpi.com
The involvement of the changed expression/function of neurotrophic factors in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD), has been …

Antidepressant-like effects of low-and high-molecular weight FGF-2 on chronic unpredictable mild stress mice

L Wang, XX Li, X Chen, XY Qin, E Kardami… - Frontiers in molecular …, 2018 - frontiersin.org
The occurrence of depressive disorder has long been attributed to changes in monoamines,
with the focus of drug treatment strategies being to change the effectiveness of monoamines …

Normal aging, motor neurone disease, and Alzheimer's disease are characterized by cortical changes in inflammatory cytokines

A Tennakoon, V Katharesan… - Journal of …, 2022 - Wiley Online Library
The role of increased brain inflammation in the development of neurodegenerative diseases
is unclear. Here, we have compared cytokine changes in normal aging, motor neurone …

Inhibition of FGF receptor-1 suppresses alcohol consumption: role of PI3 kinase signaling in dorsomedial striatum

O Even-Chen, S Barak - Journal of Neuroscience, 2019 - Soc Neuroscience
Excessive alcohol intake leads to mesostriatal neuroadaptations, and to addiction
phenotypes. We recently found in rodents that alcohol increases fibroblast growth factor 2 …

[HTML][HTML] DHA attenuates Aβ-induced necroptosis through the RIPK1/RIPK3 signaling pathway in THP-1 monocytes

S Yuan, H Li, C Yang, W Xie, Y Wang, J Zhang… - Biomedicine & …, 2020 - Elsevier
Monocytes play a crucial role in Alzheimer's disease (AD), and docosahexaenoic acid
(DHA) has a neuroprotective effect for many neurodegenerative diseases. However …

Low and high molecular weight FGF-2 have differential effects on astrocyte proliferation, but are both protective against Aβ-induced cytotoxicity

X Chen, Z Li, Y Cheng, E Kardami… - Frontiers in Molecular …, 2020 - frontiersin.org
Astrocytes are the most abundant type of glial cells in the brain, and they play a key role in
Alzheimer's disease (AD). Fibroblast Growth Factor-2 (FGF-2) has been implicated as a …

Neurotrophic, gene regulation, and cognitive functions of carboxypeptidase E-neurotrophic factor-α1 and its variants

L Xiao, X Yang, YP Loh - Frontiers in Neuroscience, 2019 - frontiersin.org
Carboxypeptidase E, also known as neurotrophic factor-α1 (CPE-NFα1), was first
discovered as an exopeptidase and is known to work by cleaving C-terminal basic amino …

Coeloglossum viride var. bracteatum extract attenuates staurosporine induced neurotoxicity by restoring the FGF2-PI3K/Akt signaling axis and Dnmt3

ZP Cai, C Cao, Z Guo, Y Yu, SJ Zhong, RY Pan… - Heliyon, 2021 - cell.com
We previously demonstrated the antioxidant activity of Coeloglossum viride var. bracteatum
extract (CE) in rat cortical neurons and in mice with chemically induced cognitive …

Immune Profiling of Secreted Factors from Human Vestibular Schwannoma Cells and Tumor‐associated Macrophages

KM Stankovic, S Batts, DB Welling… - The …, 2024 - Wiley Online Library
Objectives This study compared the immune‐related secretory capacity of human vestibular
schwannoma (VS) and tumor‐assisted macrophages (TAMs) with their normal counterparts …