Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Abstract Changes in mitochondrial morphology are associated with nutrient utilization, but
the precise causalities and the underlying mechanisms remain unknown. Here, using …

The incorporation of mitochondria into early eukaryotes established organelle-based
biochemistry and enabled metazoan development. Diverse mitochondrial biochemistry is …

Background Mitochondria are dynamic organelles that constantly change their morphology
through fission and fusion processes. Recently, abnormally increased mitochondrial fission …

Cancer cells are known for their ability to adapt variable metabolic programs depending on
the availability of specific nutrients. Our previous studies have shown that uptake of fatty …

Hypothalamic astrocytes play pivotal roles in both nutrient sensing and the modulation of
synaptic plasticity of hypothalamic neuronal circuits in control of feeding and systemic …

Fatty acids are vital for the survival of eukaryotes, but when present in excess can have
deleterious consequences. The AMP-activated protein kinase (AMPK) is an important …

Once thought of in terms of bioenergetics, mitochondria are now widely accepted as both the
orchestrator of cellular health and the gatekeeper of cell death. The pulmonary disease field …

An increasing number of studies have reported that androgens and androgen receptors
(AR) play important roles in the regulation of glucose and lipid metabolism. Impaired …

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide.
Enhanced mitochondrial fragmentation (MF) is associated with poor prognosis in HCC …