The amyloid cascade hypothesis: an updated critical review

KP Kepp, NK Robakis, PF Høilund-Carlsen, SL Sensi… - Brain, 2023 - academic.oup.com
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

C Soto, S Pritzkow - Nature neuroscience, 2018 - nature.com
A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and
accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …

A new era for understanding amyloid structures and disease

MG Iadanza, MP Jackson, EW Hewitt… - … reviews Molecular cell …, 2018 - nature.com
The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

[HTML][HTML] Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C Cheignon, M Tomas, D Bonnefont-Rousselot… - Redox biology, 2018 - Elsevier
Oxidative stress is known to play an important role in the pathogenesis of a number of
diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …

Carbon dots: advances in nanocarbon applications

Z Kang, ST Lee - Nanoscale, 2019 - pubs.rsc.org
Carbon dots (C-Dots), defined by characteristic sizes of< 10 nm, have become a rising star
in carbon nanomaterials. C-Dots possess many unique physiochemical and photochemical …

The role of amyloid-β oligomers in toxicity, propagation, and immunotherapy

U Sengupta, AN Nilson, R Kayed - EBioMedicine, 2016 - thelancet.com
The incidence of Alzheimer's disease (AD) is growing every day and finding an effective
treatment is becoming more vital. Amyloid-β (Aβ) has been the focus of research for several …

Carbon dots: biomacromolecule interaction, bioimaging and nanomedicine

Z Peng, X Han, S Li, AO Al-Youbi… - Coordination chemistry …, 2017 - Elsevier
Carbon dots, a recent member of the renowned carbon-based nanomaterials family, have
attracted significant interest from various fields. The extraordinary properties, including …

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

E Karran, M Mercken, BD Strooper - Nature reviews Drug discovery, 2011 - nature.com
The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide
in the brain is a central event in Alzheimer's disease pathology, has dominated research for …

The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization

IW Hamley - Chemical reviews, 2012 - ACS Publications
This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Alzheimer's disease: the challenge of the second century

DM Holtzman, JC Morris, AM Goate - Science translational medicine, 2011 - science.org
Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most
common cause of dementia with an estimated prevalence of 30 million people worldwide, a …