C Soto, S Pritzkow - Nature neuroscience, 2018 - nature.com
A hallmark event in neurodegenerative diseases (NDs) is the misfolding, aggregation, and accumulation of proteins, leading to cellular dysfunction, loss of synaptic connections, and …
The aggregation of proteins into amyloid fibrils and their deposition into plaques and intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …
Oxidative stress is known to play an important role in the pathogenesis of a number of diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related …
Carbon dots (C-Dots), defined by characteristic sizes of< 10 nm, have become a rising star in carbon nanomaterials. C-Dots possess many unique physiochemical and photochemical …
The incidence of Alzheimer's disease (AD) is growing every day and finding an effective treatment is becoming more vital. Amyloid-β (Aβ) has been the focus of research for several …
Z Peng, X Han, S Li, AO Al-Youbi… - Coordination chemistry …, 2017 - Elsevier
Carbon dots, a recent member of the renowned carbon-based nanomaterials family, have attracted significant interest from various fields. The extraordinary properties, including …
E Karran, M Mercken, BD Strooper - Nature reviews Drug discovery, 2011 - nature.com
The amyloid cascade hypothesis, which posits that the deposition of the amyloid-β peptide in the brain is a central event in Alzheimer's disease pathology, has dominated research for …
IW Hamley - Chemical reviews, 2012 - ACS Publications
This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
Alzheimer's disease (AD) was first described a little more than 100 years ago. It is the most common cause of dementia with an estimated prevalence of 30 million people worldwide, a …