The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

The advent of optogenetics and chemogenetics has revolutionized the study of neural circuit
mechanisms of behavioral dysregulation in psychiatric disease. These powerful …

The habenula is a complex nucleus composed of lateral and medial subnuclei, which
connect between the limbic forebrain and midbrain. Over the past few years, the lateral …

Enhancing endocannabinoid signaling produces anxiolytic-and antidepressant-like effects,
but the neural circuits involved remain poorly understood. The medial habenula (MHb) is a …

Stress management is necessary for vertebrate survival. Chronic stress drives depression by
excitation of the lateral habenula (LHb), which silences dopaminergic neurons in the ventral …

Traditional antidepressants largely interfere with monoaminergic transport or degradation
systems, taking several weeks to have their therapeutic actions. Moreover, a large …

Somatostatin is an important mood and pain-regulating neuropeptide, which exerts
analgesic, anti-inflammatory, and antidepressant effects via its Gi protein-coupled receptor …

Background The habenula is an epithalamic brain structure that acts as a neuroanatomical
hub connecting the limbic forebrain to the major monoamine centres. Abnormal habenula …

The habenula is a nuclear complex composed of the lateral habenula (LHb) and medial
habenula (MHb), two distinct structures. Much progress has been made to emphasize the …