Abstract Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic
multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural …

Pentacyclic triterpenoids comprise a largest class of natural products, bearing several
biological activities, among them anticancer activity. This chapter strolls through the …

A new pentacyclic triterpenoid constituent, characterized as 3-oxo-olean-12 (13), 18 (19)-
dien-29α-carboxylic acid (1) on the basis of detailed spectral studies, was isolated from the …

Background: It is well known that the naturally occurring modified triterpenes in plants have
a wide diversity of chemical structures and biological functions. The lupane-, oleanane-, and …

Overexpression of protein tyrosine phosphatase 1B (PTP1B) induces insulin resistance in
various basic and clinical research. In our previous work, a synthetic oleanolic acid (OA) …

Natural products and/or their derivatives represent more than half of currently available
drugs, and in the case of cancer, this proportion exceeds 60%. Triterpenoids are a large …

It was found that ozonolysis of 3-oximino-28-oxoallobetulin under normal conditions (CHCl
3, 0° C) led to the preferred formation of azepanone (lactam) ring-A (61%) and partial …

Fifteen novel 3-oxo-oleanolic acid esters bearing aryl substituted 1, 2, 3-triazolyl methyl
moiety were synthesized via the method of Copper (I)-catalyzed Huisgen cycloaddition. The …

The first oxidative transformations of 3β-acetoxy-21β-acetyl-20β, 28-epoxy-18α, 19β H-
ursane at the 21β-acetyl reaction center were performed. Ursane-type 1, 2, 4, 5-tetraoxanes …

A bench-stable combination of NaBH4-acetylacetone was developed for the efficient
chemoselective reduction of aldehydes in the presence of ketones. This method offers a …