Mitochondrial oxidative phosphorylation is incompletely coupled, since protons translocated
to the intermembrane space by specific respiratory complexes of the electron transport chain …

Abstract Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue: Function and
Physiological Significance. Physiol Rev 84: 277–359, 2004; 10.1152/physrev. 00015.2003 …

The dose-dependent toxicity to cardiomyocytes has been well recognized as a central
characteristic of doxorubicin (DOX)-induced cardiotoxicity (DIC), however, the pathogenesis …

Non-shivering thermogenesis in brown adipose tissue is mediated by uncoupling protein 1
(UCP1), which provides a carefully regulated proton re-entry pathway across the …

Extensively revised, the fourth edition of this highly successful book takes into account the
many newly determined protein structures that provide molecular insight into chemiosmotic …

Mitochondria couple respiration to ATP synthesis through an electrochemical proton
gradient. Proton leak across the inner membrane allows adjustment of the coupling …

Abstract Uncoupling protein 1 (UCP1) diverts energy from ATP synthesis to thermogenesis
in the mitochondria of brown adipose tissue by catalysing a regulated leak of protons across …

Mitochondria are potent producers of cellular superoxide, from complexes I and III of the
electron transport chain, and mitochondrial superoxide production is a major cause of the …

Mitochondria play a key role in energy metabolism in many tissues, including cardiac and
skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be …

Calorie restriction (CR) is the only experimental manipulation that is known to extend the
lifespan of a number of organisms including yeast, worms, flies, rodents and perhaps non …