Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-γ-glutamate synthetase
JW Tomsho, RG Moran, JK Coward - Biochemistry, 2008 - ACS Publications
Folylpoly-γ-glutamate synthetase (FPGS, EC 6.3. 2.17) is an ATP-dependent ligase that
catalyzes formation of poly-γ-glutamate derivatives of reduced folates and antifolates such …
catalyzes formation of poly-γ-glutamate derivatives of reduced folates and antifolates such …
5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent …
JJ McGuire, WH Haile, CC Yeh - Cancer research, 2006 - AACR
Transport is required before reduced folates and anticancer antifolates [eg, methotrexate
(MTX)] exert their physiologic functions or cytotoxic effects. The folate/antifolate transporter …
(MTX)] exert their physiologic functions or cytotoxic effects. The folate/antifolate transporter …
Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate
JJ McGuire, DM Bartley, JW Tomsho, WH Haile… - Archives of biochemistry …, 2009 - Elsevier
Phosphorus-containing pseudopeptides, racemic at the C-terminal α-carbon, are potent
mechanism-based inhibitors of folylpolyglutamate synthetase (FPGS). They are mimics of …
mechanism-based inhibitors of folylpolyglutamate synthetase (FPGS). They are mimics of …