SIRT1 is an NAD+-dependent class III histone deacetylase that is abundantly expressed in
the kidney, where it modulates gene expression, apoptosis, energy homeostasis …

Abstract The National Academy of Sciences publication, Toxicity Testing in the 21st Century:
A Vision and a Strategy, proposes a paradigm shift in toxicology from current animal-based …

The mechanisms that drive leukocyte recruitment to the kidney are incompletely understood.
Dipeptidase-1 (DPEP1) is a major neutrophil adhesion receptor highly expressed on …

Cisplatin (CP) is a widely used chemotherapeutic drug, effective against a variety of solid
tumours, though its utility is limited due to its multiple organ toxicity. Zingerone (ZO), one of …

Renal ischemia-reperfusion (I/R) injury is the most common cause of AKI, which associates
with high mortality and has no effective therapy. ELABELA (ELA) is a newly identified 32 …

Cisplatin is an effective chemotherapeutic agent that displays dose-limiting nephrotoxicity. In
the present study the wistar rats were subjected to concurrent prophylactic oral treatment of …

Background. Nephrotoxicity is the major limitation for the clinical use of cisplatin as an anti-
tumoural drug. Our aim was to investigate the protective effect of quercetin on cisplatin …

Radiographic contrast agents cause acute kidney injury (AKI), yet the underlying
pathogenesis is poorly understood. Nod-like receptor pyrin containing 3–deficient (Nlrp3 …

Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major
limitation during drug development. Multi-segmented kidney organoids derived from human …

Acute kidney injury (AKI) is characterized by an abrupt deterioration of renal function.
Formononetin (FOR) protects against cisplatin (CIS)‑induced AKI, and it has various …