The transition from genomics to phenomics in personalized population health
Modern health care faces several serious challenges, including an ageing population and
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …
Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank
M Garg, M Karpinski, D Matelska, L Middleton… - Nature Genetics, 2024 - nature.com
The emergence of biobank-level datasets offers new opportunities to discover novel
biomarkers and develop predictive algorithms for human disease. Here, we present an …
biomarkers and develop predictive algorithms for human disease. Here, we present an …
Plasma proteomic profiles predict future dementia in healthy adults
Y Guo, J You, Y Zhang, WS Liu, YY Huang, YR Zhang… - Nature Aging, 2024 - nature.com
The advent of proteomics offers an unprecedented opportunity to predict dementia onset.
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …
Aggregation-Induced Emission Luminogen: Role in Biopsy for Precision Medicine
Y Duo, L Han, Y Yang, Z Wang, L Wang… - Chemical …, 2024 - ACS Publications
Biopsy, including tissue and liquid biopsy, offers comprehensive and real-time physiological
and pathological information for disease detection, diagnosis, and monitoring. Fluorescent …
and pathological information for disease detection, diagnosis, and monitoring. Fluorescent …
Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences
Telomeres protect chromosome ends from damage and their length is linked with human
disease and aging. We developed a joint telomere length metric, combining quantitative …
disease and aging. We developed a joint telomere length metric, combining quantitative …
Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance
QS Wang, T Hasegawa, H Namkoong, R Saiki… - Nature Genetics, 2024 - nature.com
Studying the genetic regulation of protein expression (through protein quantitative trait loci
(pQTLs)) offers a deeper understanding of regulatory variants uncharacterized by mRNA …
(pQTLs)) offers a deeper understanding of regulatory variants uncharacterized by mRNA …
Whole-genome sequencing of half-a-million UK Biobank participants
Paragraph Whole-genome sequencing (WGS) provides a comprehensive view of the
genome, enabling detection of coding and non-coding genetic variation, and surveying …
genome, enabling detection of coding and non-coding genetic variation, and surveying …
Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank
The availability of protein measurements and whole exome sequence data in the UK
Biobank enables investigation of potential observational and genetic protein-cancer risk …
Biobank enables investigation of potential observational and genetic protein-cancer risk …
Protein-truncating variants in BSN are associated with severe adult-onset obesity, type 2 diabetes and fatty liver disease
Y Zhao, M Chukanova, KA Kentistou… - Nature Genetics, 2024 - nature.com
Obesity is a major risk factor for many common diseases and has a substantial heritable
component. To identify new genetic determinants, we performed exome-sequence analyses …
component. To identify new genetic determinants, we performed exome-sequence analyses …
The Circulating Proteome─ Technological Developments, Current Challenges, and Future Trends
Recent improvements in proteomics technologies have fundamentally altered our capacities
to characterize human biology. There is an ever-growing interest in using these novel …
to characterize human biology. There is an ever-growing interest in using these novel …