Usually the dense extracellular structure in fibrotic tissues is described as extracellular
matrix (ECM) or simply as collagen. However, fibrosis is not just fibrosis, which is already …

There is an unmet need for high‐quality liquid biomarkers that can safely and reproducibly
predict the stage of fibrosis and the outcomes of chronic liver disease (CLD). The …

In recent years, the basement membrane (BM)—a specialized form of extracellular matrix
(ECM)—has been recognized as an important regulator of cell behaviour, rather than just a …

Entheses (insertion sites, osteotendinous junctions, osteoligamentous junctions) are sites of
stress concentration at the region where tendons and ligaments attach to bone …

Human skin consists of a stratified, cellular epidermis and an underlying dermis of
connective tissue [1–5]. The dermal–epidermal junction is undulating in section; ridges of …

Background Angiogenesis is the process of neovascularization from pre-existing
vasculature and is involved in various physiological and pathological processes. Inhibitors …

The extracellular matrix (ECM) provides cells with positional information and a mechanical
scaffold for adhesion and migration. It consists of collagens, glycoproteins, proteoglycans …

Emerging evidence suggests that altered components and posttranslational modifications of
proteins in the extracellular matrix (ECM) may both initiate and drive disease progression …

Cell-surface/extracellular-matrix heparan-sulphate glycosaminoglycans (HSGAGs) are
complex polysaccharides that are ubiquitous in nature, and that regulate several aspects of …

Angiogenesis, the formation of new blood vessels, is required for many pathologic
processes, including invasive tumor growth as well as physiologic organ/tissue …