Biomarkers as prognostic predictors and therapeutic guide in critically ill patients: clinical evidence

R Méndez Hernández, F Ramasco Rueda - Journal of Personalized …, 2023 - mdpi.com
A biomarker is a molecule that can be measured in a biological sample in an objective,
systematic, and precise way, whose levels indicate whether a process is normal or …

Decoding sepsis-induced disseminated intravascular coagulation: a comprehensive review of existing and emerging therapies

A Unar, L Bertolino, F Patauner, R Gallo… - Journal of Clinical …, 2023 - mdpi.com
Disseminated intravascular coagulation (DIC) is a recurrent complication of sepsis. Since
DIC not only promotes organ dysfunction but also represents a strong prognostic factor, it is …

Simultaneous detection of C-reactive protein and lipopolysaccharide based on a dual-channel electrochemical biosensor for rapid Gram-typing of bacterial sepsis

TC Lu, YJ Yang, Y Zhong, QZ Qiu, ZH Chen… - Biosensors and …, 2024 - Elsevier
Sepsis is a life-threatening multi-organ failure syndrome, with bacterial infections being the
most common cause. Rapid Gram-typing is imperative to assist in antibiotic intervention. C …

Anti–miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response

MP Dragomir, E Fuentes-Mattei… - The Journal of …, 2023 - Am Soc Clin Investig
Sepsis remains a leading cause of death for humans and currently has no pathogenesis-
specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic …

Broad-Spectrum Clearance of Lipopolysaccharides from Blood Based on a Hemocompatible Dihistidine Polymer

J Chen, Z Shi, X Yang, X Zhang, D Wang… - … Applied Materials & …, 2023 - ACS Publications
Blood infection can release toxic bacterial lipopolysaccharides (LPSs) into bloodstream,
trigger a series of inflammatory reactions, and eventually lead to multiple organ dysfunction …

Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients

F Galli, F Bindo, A Motos, L Fernández-Barat… - Intensive care …, 2023 - Springer
Purpose Although the prevalence of community-acquired respiratory bacterial coinfection
upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been …

[HTML][HTML] Early lactate/albumin and procalcitonin/albumin ratios as predictors of 28-day mortality in ICU-admitted sepsis patients: A retrospective cohort study

F Li, Z Ye, J Zhu, S Gu, S Peng, Y Fang… - … Medical Journal of …, 2023 - ncbi.nlm.nih.gov
Background Lactate/albumin (LA/ALB) and procalcitonin/albumin (PCT/ALB) ratios have
been implicated in predicting mortality in sepsis patients. However, their prognostic value …

Differentiating infection, colonisation, and sterile inflammation in critical illness: the emerging role of host-response profiling

M Jeffrey, KJ Denny, J Lipman… - Intensive Care Medicine, 2023 - Springer
Infection results when a pathogen produces host tissue damage and elicits an immune
response. Critically ill patients experience immune activation secondary to both sterile and …

Monocyte distribution width (MDW) in sepsis

L Agnello, AM Ciaccio, M Vidali, A Cortegiani… - Clinica Chimica …, 2023 - Elsevier
Sepsis is a life-threatening syndrome due to a dysregulated host response to infection,
which can be caused by bacterial, viral, or fungal infection. Thus, it is crucial to know how the …

Molecular pathways in sepsis pathogenesis: Recent advances and therapeutic avenues

TA Addissouky, IET El Sayed, MMA Ali… - Journal of Cellular …, 2024 - scientificarchives.com
Molecular Pathways in Sepsis Pathogenesis: Recent Advances and Therapeutic Avenues
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