Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …

Disease-modifying therapies (DMT) for Alzheimer's disease (AD) are highly longed-for. In
this quest, antiamyloid therapies take center stage supported by genetic facts that highlight …

CYP2C8 is a crucial CYP isoform responsible for the metabolism of xenobiotics and
endogenous molecules. CYP2C8 converts arachidonic acid to epoxyeicosatrienoic acids …

The structure‐based virtual screening (SBVS) has gained immense importance in early drug
discovery. Herein, we report the SBVS‐driven identification of new cholinesterase inhibitors …

In spite of unprecedented advances in modern cancer therapy, there is still a dearth of
targeted therapy to circumvent triple-negative breast cancer (TNBC). Paclitaxel is the front …

EIDD-1931 is the active form of molnupiravir, an orally effective drug approved by the United
States Food and Drug Administration (USFDA) against COVID-19. Pharmacokinetic …

A new family of lawsone–quinoxaline hybrids was designed, synthesized, and evaluated as
dual binding site cholinesterase inhibitors (ChEIs). In vitro tests revealed that compound 6d …

Crocetin is a promising phyto-based molecule to treat Alzheimer's disease (AD). The
chemical structure of crocetin is incongruent with various standard structural features of CNS …

Heterocyclic compounds play a crucial role in the discovery of therapeutics. Alzheimer's
disease (AD) is an unfathomable sporadic neurodegenerative disorder that involves multiple …

A biologically crucial natural product rapanone 1 was isolated from Embelia ribes at the
gram scale with excellent purity. Semi-synthetic analogs of 1 semi-synthesized through …