The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

The cysteine (Cys) proteome is a major component of the adaptive interface between the
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …

Background Reactive oxygen species-mediated cysteine sulfenic acid modification has
emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic …

Cysteine residues in proteins are subject to diverse redox chemistry. Oxidation of cysteine to
S-nitrosocysteine, cysteine sulfenic and sulfinic acids, disulfides and persulfides are a few …

Protein sulfenylation is a post-translational modification of emerging importance in higher
eukaryotes. However, investigation of its diverse roles remains challenging, particularly …

Controlled generation of reactive oxygen species orchestrates numerous physiological
signaling events (Finkel, T.(2011) Signal transduction by reactive oxygen species. J. Cell …

Protein oxidative modifications, also known as protein oxidation, are a major class of protein
posttranslational modifications. They are caused by reactions between protein amino acid …

The enzymes involved in metabolism and signaling are regulated by posttranslational
modifications that influence their catalytic activity, rates of turnover, and targeting to …

Reactive oxygen species (ROS) have been long considered simply as harmful by-products
of metabolism, which damage cellular proteins, lipids, and nucleic acids. ROS are also …