Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

HE Bøtker, D Hausenloy, I Andreadou… - Basic research in …, 2018 - Springer
The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Mitochondrial fission–a drug target for cytoprotection or cytodestruction?

AA Rosdah, J K. Holien, LMD Delbridge… - Pharmacology …, 2016 - Wiley Online Library
Mitochondria are morphologically dynamic organelles constantly undergoing processes of
fission and fusion that maintain integrity and bioenergetics of the organelle: these processes …

Metabolic maturation of human pluripotent stem cell-derived cardiomyocytes by inhibition of HIF1α and LDHA

D Hu, A Linders, A Yamak, C Correia… - Circulation …, 2018 - Am Heart Assoc
Rationale: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are a readily
available, robustly reproducible, and physiologically appropriate human cell source for …

[HTML][HTML] H9c2 and HL-1 cells demonstrate distinct features of energy metabolism, mitochondrial function and sensitivity to hypoxia-reoxygenation

AV Kuznetsov, S Javadov, S Sickinger… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Dysfunction of cardiac energy metabolism plays a critical role in many cardiac diseases,
including heart failure, myocardial infarction and ischemia–reperfusion injury and organ …

Power grid protection of the muscle mitochondrial reticulum

B Glancy, LM Hartnell, CA Combs, A Femnou, J Sun… - Cell reports, 2017 - cell.com
Mitochondrial network connectivity enables rapid communication and distribution of
potential energy throughout the cell. However, this connectivity puts the energy conversion …

[图书][B] Handbook of molecular and cellular methods in biology and medicine

LJ Cseke, A Kirakosyan, PB Kaufman, MV Westfall - 2011 - books.google.com
Several milestones in biology have been achieved since the first publication of the
Handbook of Molecular and Cellular Methods in Biology and Medicine. This is true …

Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function

R Guzun, N Timohhina, K Tepp, M Gonzalez-Granillo… - Amino acids, 2011 - Springer
Physiological role of creatine (Cr) became first evident in the experiments of Belitzer and
Tsybakova in 1939, who showed that oxygen consumption in a well-washed skeletal muscle …

[HTML][HTML] Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome

R Guzun, M Gonzalez-Granillo… - … et Biophysica Acta (BBA …, 2012 - Elsevier
This review describes the recent experimental data on the importance of the VDAC–
cytoskeleton interactions in determining the mechanisms of energy and metabolite transfer …

[HTML][HTML] Structure–function relationships in feedback regulation of energy fluxes in vivo in health and disease: mitochondrial interactosome

V Saks, R Guzun, N Timohhina, K Tepp… - … et Biophysica Acta (BBA …, 2010 - Elsevier
The aim of this review is to analyze the results of experimental research of mechanisms of
regulation of mitochondrial respiration in cardiac and skeletal muscle cells in vivo obtained …

Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network

L Klepinina, A Klepinin, L Truu, V Chekulayev, H Vija… - PLoS …, 2021 - journals.plos.org
The ability of butyrate to promote differentiation of cancer cells has important implication for
colorectal cancer (CRC) prevention and therapy. In this study, we examined the effect of …