Although a wealth of data have elucidated the structure and physiology of neuronal circuits,
we still only have a very limited understanding of how behavioral learning is implemented at …

Cortical processing reflects the interplay of synaptic excitation and synaptic inhibition.
Rapidly accumulating evidence is highlighting the crucial role of inhibition in shaping …

A core component to corticolimbic circuitry is the GABAergic interneuron. Neuroanatomic
studies conducted over the past century have demonstrated several subtypes of interneuron …

The balance between excitation and inhibition in the cortex is crucial in determining sensory
processing. Because the amount of excitation varies, maintaining this balance is a dynamic …

Local circuit neurons in the dorsolateral prefrontal cortex (dPFC) of monkeys have been
implicated in the cellular basis of working memory. To further elucidate the role of inhibition …

Excitatory and inhibitory cortical layer IV neurons have distinctive response properties.
Thalamocortical connectivity that may underlie differences was examined using cross …

Isodirectional tuning of adjacent interneurons and pyramidal cells during working memory:
evidence for microcolumnar organization in PFC. Studies on the cellular mechanisms of …

Targeted delivery of neurochemicals and biomolecules for neuromodulation of brain activity
is a powerful technique that, in addition to electrical recording and stimulation, enables a …

Cortical inhibition plays an important role in shaping neuronal processing. The underlying
synaptic mechanisms remain controversial. Here, in vivo whole-cell recordings from neurons …

In layer 4 (L4) of the rat barrel cortex, a single whisker deflection evokes a stereotyped
sequence of excitation followed by inhibition, hypothesized to result in a narrow temporal …