The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key
role. An effective therapy for pain depends on the intensity and type of pain, the patients' …

Inflammatory diseases, whether caused by excessive stress on certain tissues/parts of the
body or arising from infections accompanying autoimmune or secondary diseases, have …

The supercritical antisolvent (SAS) technique has been widely employed in the biomedical
field, including drug delivery, to obtain drug particles or polymer-based systems of …

The therapeutic efficacy of orally administered drugs is often restricted by their inherent
limited oral bioavailability. Low water solubility, limited permeability through the intestinal …

Chronic inflammation contributes to the pathogenesis of many diseases, including
apparently unrelated conditions such as metabolic disorders, cardiovascular diseases …

Rhoifolin (ROF) is a bioactive plant flavonoid with potent antioxidant and anti-inflammatory
activity. However, no delivery system has yet been developed for ROF to overcome its …

Abstract Purpose of Review This review provides an update on the current status of platelet-
rich plasma (PRP). Topics covered include the current regulatory environment, economic …

Background: Symptomatic knee osteoarthritis (OA) involves millions of adults around the
world. Purpose: To analyze the effectiveness and tolerability of topical therapies and their …

Supercritical carbon dioxide adsorption was applied to incorporate three non-steroidal anti-
inflammatory drugs (NSAIDs), namely nimesulide (NIM), ketoprofen (KET) and diclofenac …

Background and objective Osteoarthritis (OA) is the most common age-related disease of
joints with increasing global prevalence. Persistent inflammation within the joint space is …