The metabolic syndrome (MetS) is characterized by a cluster of risk factors including central
obesity, hypertension, dyslipidemia and insulin resistance, The MetS is associated with an …

Wounds notoriously accumulate lactate as a consequence of both anaerobic and aerobic
glycolysis following microcirculation disruption, immune activation, and increased cell …

Peripheral arterial disease (PAD) is defined as a slow, progressive disorder of the lower
extremity arterial vessels characterized by chronic narrowing that often results in occlusion …

Aims: Peripheral artery disease is caused by the restriction or occlusion of arteries supplying
the leg. Better understanding of the molecular mechanisms underpinning tissue response to …

Background Patients with symptomatic peripheral artery disease (PAD) are at high risk of
ischemic events. However, data about predictors of this risk are limited. Hypothesis We …

While being a relatively prevalent condition particularly among aging patients, peripheral
arterial disease (PAD) of lower extremities commonly goes undetected or misdiagnosed due …

Critical limb ischemia (CLI) induces the secretion of paracrine signals, leading to monocyte
recruitment and thereby contributing to the initiation of angiogenesis and tissue healing. We …

Diabetes mellitus and its ongoing macrovascular complications represent one of the major
health problems around the world. Rise in obesity and population ages correlate with the …

Objectives The frequency and implications of peripheral artery disease (PAD) in some risk
groups are not entirely characterized in Latin America. We studied PAD prevalence, risk …

Objective Patients with extra-cardiac arterial disease (ECAD) are at high risk of coronary
artery disease (CAD). Prevalence of silent, significant CAD in patients with stenotic or …