Synthetic transformations and biological screening of benzoxazole derivatives: A review

R Sattar, R Mukhtar, M Atif… - Journal of Heterocyclic …, 2020 - Wiley Online Library
The presence of benzoxazole moiety in most of the heterocyclic compounds is well reported.
The present literature review mainly highlights the novel synthetic transformation and …

Tailored functionalization of natural phenols to improve biological activity

B Floris, P Galloni, V Conte, F Sabuzi - Biomolecules, 2021 - mdpi.com
Phenols are widespread in nature, being the major components of several plants and
essential oils. Natural phenols' anti-microbial, anti-bacterial, anti-oxidant, pharmacological …

Antifungal activities of natural products and their hybrid molecules

V Khwaza, BA Aderibigbe - Pharmaceutics, 2023 - mdpi.com
The increasing cases of drug resistance and high toxicity associated with the currently used
antifungal agents are a worldwide public health concern. There is an urgent need to develop …

Discovery of eugenol-derived drug candidates for the treatment of COVID-19 by applying molecular docking, molecular dynamics, and pharmacokinetic analysis

N Mounadi, H Nour, A Errougui, M Talbi… - Physical Chemistry …, 2024 - physchemres.org
Given the pandemic of COVID-19, the new generation of coronavirus noted SARS-CoV-2
still remains a global health threat to this day, the absence of effective and reliable …

Hybrid molecules development: A versatile landscape for the control of antifungal drug resistance: A review

CG Anusionwu, BA Aderibigbe… - Mini Reviews in …, 2019 - ingentaconnect.com
Hybrid molecule approach of drug design has become popular due to advantages such as
delayed resistance, reduced toxicity, ease of treatment of co-infection and lower cost of …

Anti‐Candida, docking studies, and in vitro metabolism‐mediated cytotoxicity evaluation of Eugenol derivatives

JAP Dutra, SC Maximino… - Chemical Biology & …, 2023 - Wiley Online Library
The high morbidity and mortality rates of Candida infections, especially among
immunocompromised patients, are related to the increased resistance rate of these species …

In Vitro Anti-Candida Activity and Action Mode of Benzoxazole Derivatives

M Staniszewska, Ł Kuryk, A Gryciuk, J Kawalec… - Molecules, 2021 - mdpi.com
A newly synthetized series of N-phenacyl derivatives of 2-mercaptobenzoxazole, including
analogues of 5-bromo-and 5, 7-dibromobenzoxazole, were screened against Candida …

[HTML][HTML] Exploring how structural changes to new Licarin A derivatives effects their bioactive properties against rapid growing mycobacteria and biofilm formation

DJ Alvarenga, LMF Matias, LM Oliveira… - Microbial …, 2020 - Elsevier
Several species of rapidly growing mycobacteria (RGM) have been associated with biofilms
in areas such as biomedical devices, water distribution systems, cosmetic surgery, and …

Targeting disease with benzoxazoles: a comprehensive review of recent developments

A Abdullahi, KY Yeong - Medicinal Chemistry Research, 2024 - Springer
Benzoxazole is an attractive scaffold in medicinal chemistry due to its diverse biological
applications. From 2016 to 2023, a plethora of benzoxazole derivatives have been …

Biological activity of 3-(2-benzoxazol-5-yl) alanine derivatives

K Guzow, E Mulkiewicz, M Obuchowski, W Wiczk - Amino Acids, 2021 - Springer
Searching for new drugs is still a challenge for science, mainly because of civilization
development and globalization which promote the rapid spread of diseases, which is …