Fungal infections are a universal problem and are routinely associated with high morbidity
and mortality rates in immunocompromised patients. Existing therapies comprise five …

Filamentous and dimorphic fungi cause invasive mycoses associated with high mortality
rates. Among the fungal determinants involved in the establishment of infection …

Cryptococcus neoformans is an encapsulated fungal pathogen that causes
meningoencephalitis. There are no prophylactic tools for cryptococcosis. Previously, our …

Ceramide synthases (CerSs) play crucial roles in sphingolipid metabolism and have
emerged as promising drug targets for metabolic diseases, cancers, and antifungal therapy …

The ability for cells to maintain homeostasis in the presence of extracellular stress is
essential for their survival. Stress adaptations are especially important for microbial …

ABSTRACT SCS7 is a fatty acid 2-hydroxylase required for the synthesis of inositol
phosphorylceramide but is not essential for normal growth in Saccharomyces cerevisiae …

ABSTRACT AFP is an antimicrobial peptide (AMP) produced by the filamentous fungus
Aspergillus giganteus and is a very potent inhibitor of fungal growth that does not affect the …

Thermotolerance is a remarkable virulence attribute of Aspergillus fumigatus, but the
consequences of heat shock (HS) to the cell membrane of this fungus are unknown …

Lipids play a fundamental role in fungal cell biology, being essential cell membrane
components and major targets of antifungal drugs. A deeper knowledge of lipid metabolism …

Phosphatidylinositol phosphates are key phospholipids with a range of regulatory roles,
including membrane trafficking and cell polarity. Phosphatidylinositol-4-phosphate [PI (4) P] …