Simulating tissue mechanics with agent-based models: concepts, perspectives and some novel results

P Van Liedekerke, MM Palm, N Jagiella… - Computational particle …, 2015 - Springer
In this paper we present an overview of agent-based models that are used to simulate
mechanical and physiological phenomena in cells and tissues, and we discuss underlying …

Challenges and opportunities for small volumes delivery into the skin

M Mercuri, D Fernandez Rivas - Biomicrofluidics, 2021 - pubs.aip.org
Each individual's skin has its own features, such as strength, elasticity, or permeability to
drugs, which limits the effectiveness of one-size-fits-all approaches typically found in …

Meshfree and particle methods in biomechanics: Prospects and challenges

LW Zhang, AS Ademiloye, KM Liew - Archives of Computational Methods …, 2019 - Springer
The use of meshfree and particle methods in the field of bioengineering and biomechanics
has significantly increased. This may be attributed to their unique abilities to overcome most …

Single-cell characterization of deformation and dynamics of mesenchymal stem cells in microfluidic systems: A computational study

X Qi, S Ma, X Jiang, H Wu, J Zheng, S Wang, K Han… - Physical Review E, 2023 - APS
Understanding the homing dynamics of individual mesenchymal stem cells (MSCs) in
physiologically relevant microenvironments is crucial for improving the efficacy of MSC …

[HTML][HTML] Discovery of quasi-disordered truss metamaterials inspired by natural cellular materials

AS Bhuwal, Y Pang, I Ashcroft, W Sun, T Liu - Journal of the Mechanics and …, 2023 - Elsevier
Natural cellular materials, such as marine mussels, honeycombs, woods, trabecular bones,
plant parenchyma, sponges and protoreaster nodosus, may benefit from the disorderliness …

A quantitative high-resolution computational mechanics cell model for growing and regenerating tissues

P Van Liedekerke, J Neitsch, T Johann… - … and modeling in …, 2020 - Springer
Mathematical models are increasingly designed to guide experiments in biology,
biotechnology, as well as to assist in medical decision making. They are in particular …

Universal phase-field mixture representation of thermodynamics and shock-wave mechanics in porous soft biologic continua

JD Clayton - Physical Review E, 2024 - APS
A continuum mixture theory is formulated for large deformations, thermal effects, phase
interactions, and degradation of soft biologic tissues suitable at high pressures and low to …

Internal mechanical damage prediction in tomato compression using multiscale finite element models

Z Li, P Li, H Yang, J Liu - Journal of Food Engineering, 2013 - Elsevier
The mechanical damage of exocarp, mesocarp and locular gel tissues of three and four
locular tomatoes subjected to an external compressive force were predicted using multiscale …

Analysis of initial cell spreading using mechanistic contact formulations for a deformable cell model

T Odenthal, B Smeets, P Van Liedekerke… - PLoS computational …, 2013 - journals.plos.org
Adhesion governs to a large extent the mechanical interaction between a cell and its
microenvironment. As initial cell spreading is purely adhesion driven, understanding this …

Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines

P Van Liedekerke, J Neitsch, T Johann… - PLoS computational …, 2019 - journals.plos.org
Model simulations indicate that the response of growing cell populations on mechanical
stress follows the same functional relationship and is predictable over different cell lines and …